There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Atosiban acetate (also known as RW22164 acetate or RWJ22164 acetate), a nonapeptide, functions as a competitive antagonist to vasopressin/oxytocin receptors and is an analog of desamino-oxytocin. It is primarily used as a tocolytic agent for the investigation of spontaneous preterm labor[1].
体内研究
The neuropeptides oxytocin and arginine vasopressin, which only differ by two amino acids, are both posterior pituitary hormones. Atosiban modulates the arginine vasopressin-induced physiological impacts on the cardiovascular and renal systems of the fetus and mother. In experiments involving late-gestation sheep, administering Atosiban for one hour does not result in any fetomaternal cardiovascular modifications[1].
Atosiban also inhibits the activation of neurons expressing oxytocin receptors in the parabrachial nucleus of mice[2].
体外研究
Atosiban prevents the release of IP3 triggered by oxytocin from the myometrial cell membrane, thereby reducing the release and influx of calcium within myometrial cells, and diminishing oxytocin-induced release of PGE and PGF from the decidua[1].
Single injection, social interaction test conducted 30 min post-infusion
Atosiban reduced social approach by inhibiting OTR-Gq signaling without increasing social vigilance.
Neuropsychopharmacology. 2020 Aug;45(9):1423-1430
ICR mice
Tamoxifen-induced adenomyosis mouse model
Intraperitoneal injection
1 mg/kg
Once daily for 3 weeks
To evaluate the effects of atosiban on tamoxifen-induced adenomyosis mice. Results showed that after 3 weeks of atosiban treatment, the hot plate response latency was significantly prolonged, indicating its antinociceptive effect. However, the reduction in the depth of myometrial infiltration was not significant.
Drug Des Devel Ther. 2025 Apr 2;19:2533-2549
Male Sprague-Dawley rats
Single prolonged stress (SPS) model
Intraperitoneal injection
5 mg/kg
30 minutes prior to OXT delivery
Atosiban blocked the ameliorative effect of OXT on SPS-induced social behavior deficits.
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