Amenamevir (ASP2151) inhibits the replication of HSV strains isolated from Japan, the United States, and laboratory-stocked strains. The EC50s of Amenamevir against HSV-1 and HSV-2 are significantly lower than those of acyclovir (ACV) [1].
体内研究
Amenamevir (ASP2151) administration reduces virus titer and lesion scores in a dose-dependent manner. PK parameters for complete suppression of HSV-1 growth by Amenamevir are estimated [1].
体外研究
Amenamevir (ASP2151) inhibits the replication of HSV strains isolated from Japan, the United States, and laboratory-stocked strains. The EC50s of Amenamevir against HSV-1 and HSV-2 are significantly lower than those of acyclovir (ACV) [1].
Amenamevir/阿莫奈韦 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Vero cells
0.01 μM to 0.5 μM
2 to 3 days
To screen for AMNV-resistant HSV-1 and HSV-2 mutants
To evaluate the inhibitory effect of ASP2151 on HSV-1 and HSV-2, results showed ASP2151 more potently inhibited viral replication than acyclovir (ACV).
To evaluate the in vitro antiviral activity of ASP2151 against HSV-1 and HSV-2. Results showed that ASP2151 had EC50 values of 14 ng/ml for HSV-1 and 30 ng/ml for HSV-2, significantly lower than those of acyclovir (ACV).
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