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/ Acarbose/阿卡波糖

Acarbose/阿卡波糖 {[allProObj[0].p_purity_real_show]}

货号：A357603 同义名： 阿卡波糖水合物 / BAY g 5421

Acarbose 是一种肠道 α-葡萄糖苷酶抑制剂，常用于 2 型糖尿病的研究。

Acarbose/阿卡波糖 化学结构 CAS号：56180-94-0
Acarbose/阿卡波糖 化学结构
CAS号：56180-94-0
Acarbose/阿卡波糖 3D分子结构
CAS号：56180-94-0
Acarbose/阿卡波糖 化学结构 CAS号：56180-94-0
Acarbose/阿卡波糖 3D分子结构 CAS号：56180-94-0
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Acarbose/阿卡波糖 纯度/质量文件 产品仅供科研

货号：A357603 标准纯度： {[allProObj[0].p_purity_real_show]}
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Acarbose/阿卡波糖 生物活性

描述 α-glucosidases are enzymes responsible for the metabolism of complex carbohydrates into absorbable monosaccharide units. However, hyperglycemia causes a number of abnormalities which contribute to the development of long-term complications of diabetes. Acarbose, an anti-diabetic drug, is an intestinal α-glucosidase inhibitor[3]. In TNF-α pre-treated A7r5 cells, acarbose (1, 2, and 3 μM) dose-dependently decreased β-galactosidase, Ras expression and increased p-AMPK expression. In HCD (high cholesterol diet)-fed rabbits, the numbers of atherosclerotic plaques in the aortic arch were significantly decreased by acarbose treatment (2.5 and 5.0 mg/kg per day). Further, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased the intensity of neointimal IL-6, TNF-α, and iNOS staining, and significantly increased the intensity of neointimal p-AMPK staining. Moreover, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased neointimal Ras and β-galactosidase expression in HCD-fed rabbits[4].

Acarbose/阿卡波糖 细胞实验

Cell Line
Concentration Treated Time Description References
Bone marrow-derived macrophages (BMDMs) 250 μM 48 h To investigate the direct effects of Acarbose on the survival and proinflammatory function of M1-polarized macrophages. Results showed that Acarbose significantly increased apoptosis of M1-polarized macrophages and reduced TNF-α secretion. Cell Rep Med. 2025 Jan 21;6(1):101883
Bacteroides ovatus (Bo) 25 µM 144 h To evaluate the effect of Acarbose on the growth of different Bacteroides species, it was found that Bo growth is much less affected. mBio. 2024 Dec 11;15(12):e0150624
Bacteroides thetaiotaomicron (Bt) 25 µM 144 h To evaluate the effect of Acarbose on the growth of different Bacteroides species, it was found that Bt growth on starch polysaccharides is severely impaired. mBio. 2024 Dec 11;15(12):e0150624
Macrophages 10.0 µg/mL 48 h Assess the therapeutic effect of Acarbose on L. infantum-infected macrophages, resulting in an 87.4% reduction in infectivity. Med Microbiol Immunol. 2021 Jun;210(2-3):133-147
L. infantum promastigotes 0.47 ± 0.1 µg/mL (IC50) 48 h Evaluate the direct antileishmanial activity of Acarbose against L. infantum promastigotes, showing significant inhibitory effects. Med Microbiol Immunol. 2021 Jun;210(2-3):133-147

Acarbose/阿卡波糖 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Apc+/Min mouse model Oral 296 ppm and 935 ppm Continuous feeding starting at 42 days of age Acarbose improved the median survival of Apc+/Min mice, with low dose (296 ppm) and high dose (935 ppm) increasing survival by 15.2% and 21.4%, respectively. The high dose also reduced tumor number and improved hematocrit. Aging Cell. 2020 Feb;19(2):e13088
HET3 mice Genetically heterogeneous mice Dietary administration 400, 1000, 2500 ppm Continuous administration starting at 8 months of age Acarbose significantly extended the lifespan of male mice with smaller effects in females. Higher doses of acarbose reduced lung tumors in males, diminished liver degeneration in both sexes and glomerulosclerosis in females, reduced blood glucose responses to refeeding in males, and improved rotarod performance in aging females, but not males. Aging Cell. 2019 Apr;18(2):e12898
Mice UM-HET3 mice Diet 1000 ppm Continuous administration starting from 4 months of age To evaluate the effects of acarbose on lifespan. Results showed that acarbose significantly increased male median lifespan by 22% (P<0.0001), but only increased female median lifespan by 5% (P=0.01). Maximum lifespan (90th percentile) increased by 11% (P<0.001) in males and 9% (P=0.001) in females. Aging Cell. 2014 Apr;13(2):273-82
3xTg and non-transgenic (NTg) mice Alzheimer’s disease model Dietary administration 1000 ppm Started at 6 months of age and continued for 6 months Acarbose ameliorates Western diet-induced metabolic and cognitive impairments, reduces body weight and adiposity, increases energy expenditure, improves glycemic control, and reverses WD-induced cognitive deficits. Geroscience. 2025 Apr;47(2):1569-1591
C57BL/6J mice High-fat diet-induced type 2 diabetic mouse model Oral gavage 40 mg/kg Once daily for two weeks To investigate the effect and mechanism of acarbose on Pseudomonas aeruginosa respiratory tract infection in T2DM and non-diabetic mice. Results showed that acarbose treatment significantly reduced mortality, alleviated lung inflammation, and decreased infection severity in both diabetic and non-diabetic mice. Respir Res. 2023 Dec 14;24(1):312

Acarbose/阿卡波糖 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02476760 - Completed - Canada, Quebec ... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 收起 <<
NCT02475499 - Completed - Canada, Quebec ... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 收起 <<
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<

Acarbose/阿卡波糖 参考文献

[1]Okada K, Yanagawa T, et al. The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice. Hepatol Res. 2009 May;39(5):490-500.

[2]Wang PY, Kaneko T, et al. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology. 1999 Jan;29(1):161-5.

[3]Martin AE, Montgomery PA. Acarbose: an alpha-glucosidase inhibitor. Am J Health Syst Pharm. 1996 Oct 1;53(19):2277-90

[4]Chan KC, Yu MH, Lin MC, Huang CN, Chung DJ, Lee YJ, Wu CH, Wang CJ. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:38642

Acarbose/阿卡波糖 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.55mL

0.31mL

0.15mL

7.74mL

1.55mL

0.77mL

15.49mL

3.10mL

1.55mL

Acarbose/阿卡波糖 技术信息

CAS号56180-94-0
分子式C25H43NO18
分子量 645.6
SMILES Code O[C@H]1[C@]([H])(O[C@H]([C@@H]2O)O[C@@H]([C@H]([C@@H]2O)N[C@@]([H])(C=C3CO)[C@H](O)[C@H]([C@@H]3O)O)C)[C@@H](CO)O[C@@H]([C@@H]1O)O[C@@]([H])([C@@H]([C@H](C=O)O)O)[C@@H](CO)O
MDL No. MFCD00869592
别名 阿卡波糖水合物 ;BAY g 5421
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C
溶解方案

H2O: 100 mg/mL(154.89 mM)，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Acarbose | BAY g 5421 | 阿卡波糖水合物 | Diabete | Starch Glucosidase Inhibitor | Inosine Monophosphate (IMP) Dehydrogenase Inhibitor | Glucosidase | AmBeed-信号通路专用抑制剂 | Acarbose/阿卡波糖 纯度/质量文件 | Acarbose/阿卡波糖 生物活性 | Acarbose/阿卡波糖 临床数据 | Acarbose/阿卡波糖 参考文献 | Acarbose/阿卡波糖 实验方案 | Acarbose/阿卡波糖 技术信息

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