7,4'-Di-O-methylapigenin
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货号：A446385
同义名：
4',7-Dimethoxy-5-Hydroxyflavone; Acacetin 7-methyl ether
7,4'-Di-O-methylapigenin 是一种从沉香中提取的黄酮类化合物，可抑制 α-葡萄糖苷酶（IC50 = 51.64 μg/mL）和 α-淀粉酶，并增强细胞葡萄糖摄取，适用于糖尿病及代谢紊乱的研究。
7,4'-Di-O-methylapigenin 化学结构
7,4'-Di-O-methylapigenin 3D分子结构
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7,4'-Di-O-methylapigenin 纯度/质量文件 产品仅供科研
货号：A446385
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7,4'-Di-O-methylapigenin 质控信息
7,4'-Di-O-methylapigenin 生物活性
描述
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml[3] [4]
7,4'-Di-O-methylapigenin 参考文献
[1] Krishna MS, Joy B, Sundaresan A. Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4'-dimethyl ether isolated from Piper longum L. J Food Sci Technol. 2015 Jun;52(6):3561-70.
[2] Zahir A, Jossang A, et al. Five new flavone 5-O-glycosides from Lethedon tannaensis: lethedosides and lethediosides. J Nat Prod. 1999 Feb;62(2):241-3.
[3] Alvarez ME, Rotelli AE, Pelzer LE, Saad JR, Giordano O. Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke. Farmaco. 2000 Jun-Jul;55(6-7):502-5
[4] Mangoyi R, Midiwo J, Mukanganyama S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC Complement Altern Med. 2015 Nov 14;15:405
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7,4'-Di-O-methylapigenin 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.35mL
0.67mL
0.34mL
16.76mL
3.35mL
1.68mL
33.52mL
6.70mL
3.35mL
7,4'-Di-O-methylapigenin 技术信息
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