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描述 | 6-APA (6-aminopenicillanic acid), is used to prepare raw materials for semi synthetic penicillin. In the fermentation broth of P. chrysogenum it is necessary to distinguish between the primary 6-APA which is a product of the biosynthesis via L-cystine/D-valine and the secondary 6-APA which originates from isopenicillin N[2]. The overall yield of 6-APA crystals obtained after enzymatic conversion of penicillin G ranged between 37-55 and 47-68% in foreign and local strains, respectively[3]. Moreover, 6-APA slightly reduced the exogenous acetylcholine-induced contractile response and this effect was a little weaker than it is on the intramural electrical stimulation-induced contractile response[4]. Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli[5]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.62mL 0.92mL 0.46mL |
23.12mL 4.62mL 2.31mL |
46.24mL 9.25mL 4.62mL |
CAS号 | 551-16-6 |
分子式 | C8H12N2O3S |
分子量 | 216.26 |
SMILES Code | [C@H]12SC([C@@H](N1C(=O)[C@H]2N)C(=O)O)(C)C |
MDL No. | MFCD00005176 |
别名 | 6-APA; NSC 50071; 6β-Aminopenicillanic Acid; (+)-6-Aminopenicillanic Acid |
运输 | 蓝冰 |
InChI Key | NGHVIOIJCVXTGV-ALEPSDHESA-N |
Pubchem ID | 11082 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, 2-8°C |
溶解方案 |
0.1 M HCL: 10 mg/mL(46.24 mM),配合低频超声,并调节pH至2 0.1 M NaOH: 5 mg/mL(23.12 mM),配合低频超声助溶 |