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6-Aminopenicillanic acid/6-氨基青霉烷酸 {[allProObj[0].p_purity_real_show]}

货号:A141395 同义名: 6-APA; NSC 50071

6-APA是青霉素类药物的核心部分。

6-Aminopenicillanic acid/6-氨基青霉烷酸 化学结构 CAS号:551-16-6
6-Aminopenicillanic acid/6-氨基青霉烷酸 化学结构
CAS号:551-16-6
6-Aminopenicillanic acid/6-氨基青霉烷酸 3D分子结构
CAS号:551-16-6
6-Aminopenicillanic acid/6-氨基青霉烷酸 化学结构 CAS号:551-16-6
6-Aminopenicillanic acid/6-氨基青霉烷酸 3D分子结构 CAS号:551-16-6
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6-Aminopenicillanic acid/6-氨基青霉烷酸 纯度/质量文件 产品仅供科研

货号:A141395 标准纯度: {[allProObj[0].p_purity_real_show]}
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6-Aminopenicillanic acid/6-氨基青霉烷酸 生物活性

描述 6-APA (6-aminopenicillanic acid), is used to prepare raw materials for semi synthetic penicillin. In the fermentation broth of P. chrysogenum it is necessary to distinguish between the primary 6-APA which is a product of the biosynthesis via L-cystine/D-valine and the secondary 6-APA which originates from isopenicillin N[2]. The overall yield of 6-APA crystals obtained after enzymatic conversion of penicillin G ranged between 37-55 and 47-68% in foreign and local strains, respectively[3]. Moreover, 6-APA slightly reduced the exogenous acetylcholine-induced contractile response and this effect was a little weaker than it is on the intramural electrical stimulation-induced contractile response[4]. Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli[5].

6-Aminopenicillanic acid/6-氨基青霉烷酸 参考文献

[1]Batchelor FR, Doyle FP, et al. Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentations. Nature. 1959 Jan 24;183(4656):257-8.

[2]Bosnic P, Gelineo A, Gajic B. Biogenez 6-aminopenitsillanovoĭ kisloty (6-APK) i penitsillina u Penicillium chrysogenum; éffekt biokatalizatora khrizina [Biogenesis of 6-aminopenicillanic acid (6-APA) and penicillin in Penicillium chrysogenum: effect of the biocatalyst chrysin]. Antibiot Khimioter. 1994;39(9-10):6–11

[3]Arshad R, Farooq S, Ali SS. 6-aminopenicillanic acid production by intact cells of E. coli containing penicillin G acylase (PGA). Pak J Biol Sci. 2007;10(18):3190–3194

[4]Yoshida M, Koeda T. Effects of aminobenzyl penicillin (AB-PC), methylchlorophenyl isoxazolyl penicillin (MCI-PC) and 6-aminopenicillanic acid (6-APA) on the contractile response of guinea-pig urinary bladder. Nihon Heikatsukin Gakkai Zasshi. 1984;20(1):1–12

[5]Lorian V, Atkinson B. Comparison of the effects of mecillinam and 6-aminopenicillanic acid on Proteus mirabilis, Escherichia coli, and Staphylococcus aureus. Antimicrob Agents Chemother. 1977;11(3):541–552

6-Aminopenicillanic acid/6-氨基青霉烷酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.62mL

0.92mL

0.46mL

23.12mL

4.62mL

2.31mL

46.24mL

9.25mL

4.62mL

6-Aminopenicillanic acid/6-氨基青霉烷酸 技术信息

CAS号551-16-6
分子式C8H12N2O3S
分子量 216.26
SMILES Code [C@H]12SC([C@@H](N1C(=O)[C@H]2N)C(=O)O)(C)C
MDL No. MFCD00005176
别名 6-APA; NSC 50071; 6β-Aminopenicillanic Acid; (+)-6-Aminopenicillanic Acid
运输蓝冰
InChI Key NGHVIOIJCVXTGV-ALEPSDHESA-N
Pubchem ID 11082
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

溶解方案

0.1 M HCL: 10 mg/mL(46.24 mM),配合低频超声,并调节pH至2

0.1 M NaOH: 5 mg/mL(23.12 mM),配合低频超声助溶

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