生物活性 | |||
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描述 | 6-APA (6-aminopenicillanic acid), is used to prepare raw materials for semi synthetic penicillin. In the fermentation broth of P. chrysogenum it is necessary to distinguish between the primary 6-APA which is a product of the biosynthesis via L-cystine/D-valine and the secondary 6-APA which originates from isopenicillin N[2]. The overall yield of 6-APA crystals obtained after enzymatic conversion of penicillin G ranged between 37-55 and 47-68% in foreign and local strains, respectively[3]. Moreover, 6-APA slightly reduced the exogenous acetylcholine-induced contractile response and this effect was a little weaker than it is on the intramural electrical stimulation-induced contractile response[4]. Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli[5]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.62mL 0.92mL 0.46mL |
23.12mL 4.62mL 2.31mL |
46.24mL 9.25mL 4.62mL |
参考文献 |
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