6-Aminopenicillanic acid
产品说明书
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同义名 : | 6-APA; NSC 50071; 6β-Aminopenicillanic Acid; (+)-6-Aminopenicillanic Acid |
| CAS号 : | 551-16-6 | |
| 货号 : | A141395 | |
| 分子式 : | C8H12N2O3S | |
| 纯度 : | 95% | |
| 分子量 : | 216.26 | |
| MDL号 : | MFCD00005176 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
0.1 M HCL: 10 mg/mL(46.24 mM)，配合低频超声，并调节pH至2 0.1 M NaOH: 5 mg/mL(23.12 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 6-APA (6-aminopenicillanic acid), is used to prepare raw materials for semi synthetic penicillin. In the fermentation broth of P. chrysogenum it is necessary to distinguish between the primary 6-APA which is a product of the biosynthesis via L-cystine/D-valine and the secondary 6-APA which originates from isopenicillin N[2]. The overall yield of 6-APA crystals obtained after enzymatic conversion of penicillin G ranged between 37-55 and 47-68% in foreign and local strains, respectively[3]. Moreover, 6-APA slightly reduced the exogenous acetylcholine-induced contractile response and this effect was a little weaker than it is on the intramural electrical stimulation-induced contractile response[4]. Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.62mL 0.92mL 0.46mL |
23.12mL 4.62mL 2.31mL |
46.24mL 9.25mL 4.62mL |
| 参考文献 |
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