4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations, it also has estrogenic activities.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
4-Methylbenzylidene camphor (4-MBC), functioning as an endocrine disruptor, mimics estrogen and impacts human trophoblast cells by reducing their proliferation and triggering apoptosis. It activates the PI3K/AKT and ERK1/2 signaling pathways and increases the production of intracellular reactive oxygen species (ROS). As a UV filter, 4-MBC could interfere with normal placental development in early pregnancy[1].[2].
体内研究
When administered in chow at doses of 0.7, 7, 24, and 47 mg/kg/day to the parent generation prior to mating, during pregnancy and lactation, and to offspring until adulthood, 4-MBC results in increased prostate growth and altered gene expression in the uterus of neonates[1].
体外研究
In HTR8/SVneo cells, 4-MBC at concentrations of 5-400 μM over 48 hours inhibits cell proliferation[1].
At doses of 10-50 μM for 48 hours, 4-MBC leads to apoptotic death in human trophoblast cell[1].
Using 5-50 μM of 4-MBC for 48 hours increases the proportion of cells in the SubG1 phase, indicating cell cycle disruption[1].
With 50 μM for 48 hours, it also reduces the invasive capability of human trophoblast cells[1].
Exposure to 50 μM of 4-MBC for durations ranging from 5 to 120 minutes activates the PI3K/AKT and ERK1/2 pathways in these cells[1].
At concentrations of 20-50 μM over 24 hours, there is a notable upregulation in the expression of genes SEMA6 A, GPR56, ITGB4, EPHB4, and NRP1[1].
搜索
HazMat Fee +
