There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
3,3'-Difluorobenzaldazine (DFB) acts as a selective positive allosteric modulator of mGluR5, enhancing the effect of mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine) by 3- to 6-fold with EC50 values between 2 and 5 μM[1].
体内研究
3,3'-Difluorobenzaldazine (40-100 nmol; icv) mitigates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2].
体外研究
3,3'-Difluorobenzaldazine (DFB) shows concentration-dependent enhancement of human mGluR5 CHO cells' response to 300 nM glutamate. The maximum enhancement reaches approximately 3.1-fold with an EC50 of 2.6 μM. 3,3'-Difluorobenzaldazine similarly boosts responses in both human and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable efficacies[1].
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