3,3'-Difluorobenzaldazine

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Chemical Structure| 15332-10-2 同义名 : DFB
CAS号 : 15332-10-2
货号 : A261426
分子式 : C14H10F2N2
纯度 : 99%+
分子量 : 244.24
MDL号 : MFCD03653615
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 3,3'-Difluorobenzaldazine (DFB) acts as a selective positive allosteric modulator of mGluR5, enhancing the effect of mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine) by 3- to 6-fold with EC50 values between 2 and 5 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL
参考文献

[1]O'Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740.

[2]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740.