10-Gingerol, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe. with anti-neuroinflammatory capacity, effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation, induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells, and induces apoptosis accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
10-Gingerol/10-姜酚 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MCF-10A
0, 25, 50, 100, 150, 200, 400, 800 μM
48 h
10-G showed low inhibition on non-tumor breast epithelial cell MCF-10A and did not enhance the cytotoxicity of paclitaxel.
Drug Des Devel Ther. 2023 Jan 20;17:129-142
SUM-159
0, 25, 50, 100, 150, 200, 400, 800 μM
48 h
10-G inhibited the proliferation of SUM-159 cells in a concentration-dependent manner and increased their sensitivity to paclitaxel.
Drug Des Devel Ther. 2023 Jan 20;17:129-142
MDA-MB-231
0, 25, 50, 100, 150, 200, 400, 800 μM
48 h
10-G inhibited the proliferation of MDA-MB-231 cells in a concentration-dependent manner and increased their sensitivity to paclitaxel.
Drug Des Devel Ther. 2023 Jan 20;17:129-142
rat bone marrow-derived osteoclast precursors
2.5 μM
6 days
10-gingerol reduced the number of osteoclasts in TRAP staining.
Front Cell Dev Biol. 2021 Mar 3;9:588093
RAW264.7 cells
2.5 μM
6 days
10-gingerol significantly suppressed RANKL-induced osteoclast differentiation in RAW264.7 cells, reducing the number of TRAP-positive multinucleated osteoclasts.
Front Cell Dev Biol. 2021 Mar 3;9:588093
MDA-MB-231/IR cells
90 µM
24 h
To evaluate the effects of 10-gingerol on the invasive ability of MDA-MB-231/IR cells. Results showed that 10-gingerol significantly reduced the number of invading MDA-MB-231/IR cells.
Molecules. 2020 Jul 10;25(14):3164
MDA-MB-231/IR cells
90, 45 µM
24 h
To evaluate the effects of 10-gingerol on the migratory ability of MDA-MB-231/IR cells. Results showed that 10-gingerol significantly inhibited the migratory ability of MDA-MB-231/IR cells.
Molecules. 2020 Jul 10;25(14):3164
MDA-MB-231/IR cells
40, 20, 10, 5 µM
10 days
To evaluate the effects of 10-gingerol on the clonogenic ability of MDA-MB-231/IR cells. Results showed that 10-gingerol significantly reduced the clonogenic ability of MDA-MB-231/IR cells.
Molecules. 2020 Jul 10;25(14):3164
MCF-10A cells
200, 100, 50, 25, 12.5, 6.25 µM
24 and 48 h
To evaluate the cytotoxic effects of 10-gingerol on normal mammary epithelial cells. Results showed that 10-gingerol exerted fewer cytotoxic effects in MCF-10A cells than the positive control docetaxel.
Molecules. 2020 Jul 10;25(14):3164
MDA-MB-231/IR cells
200, 100, 50, 25, 12.5, 6.25 µM
24 and 48 h
To evaluate the inhibitory effects of 10-gingerol on the proliferation of MDA-MB-231/IR cells. Results showed that 10-gingerol suppressed the proliferation of MDA-MB-231/IR cells in a dose and time-dependent manner.
Molecules. 2020 Jul 10;25(14):3164
HepG2 cells
10 µM
48 h
To investigate the effect of 10-Gingerol on CYP3A4 mRNA expression. Results showed that 10-Gingerol inhibited CYP3A4 mRNA expression by 61%±4%.
Acta Pharmacol Sin. 2013 Sep;34(9):1237-42
10-Gingerol/10-姜酚 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
NOD/SCID mice
Breast cancer xenograft model
Oral
40 mg/kg
Once daily for 33 days
10-G enhanced the anti-tumor effects of paclitaxel in the TNBC xenograft model without increasing hepatorenal toxicity.
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