10-Gingerol

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Chemical Structure| 23513-15-7 同义名 : (S)-[10]-Gingerol
CAS号 : 23513-15-7
货号 : A151653
分子式 : C21H34O4
纯度 : 99%+
分子量 : 350.49
MDL号 : MFCD01682694
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(299.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 10-Gingerol, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe. with anti-neuroinflammatory capacity, effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation, induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells, and induces apoptosis accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.29mL

14.27mL

2.85mL

1.43mL

28.53mL

5.71mL

2.85mL
参考文献

[1]Ryu MJ, Chung HS. [10] -Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells. In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):92-101.

[2]Ho SC, Chang KS, Lin CC. Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol. Food Chem. 2013 Dec 1;141(3):3183-91.