1-Palmitoyl-sn-glycero-3-phosphocholine, a prevalent lysophosphatidylcholine, displays proinflammatory effects. It is utilized in researching atherosclerosis[1][2][3][4].
体内研究
1-Palmitoyl-sn-glycero-3-phosphocholine (10 mg/kg, subcutaneous injection) improves neutrophil activity, bacterial elimination, and survival rates in a sepsis mouse model[4].
体外研究
1-Palmitoyl-sn-glycero-3-phosphocholine (125 μM, 2 h) causes superoxide overload in HUVECs by inhibiting SOD1, leading to decreased levels of phosphorylated ERK1/2 and eNOS[1].
1-Palmitoyl-sn-glycero-3-phosphocholine (0.3, 1 μM, 24 h) increases the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-activated M1 macrophages[2].
1-Palmitoyl-sn-glycero-3-phosphocholine (10 μM, 24 h) boosts TGF-β1 production and elevates Foxp3 protein levels in human peripheral blood Treg cells isolated from samples[3].
To test the effect of 1-palmitoyl-sn-glycero-3-phosphocholine on HepG2 cell proliferation. Results showed no significant inhibition of cell proliferation.
Mar Drugs. 2020 Mar 17;18(3):166
A2058 cells
3.13, 6.25, 12.5, 25, and 50 μg/mL
72 h
To test the effect of 1-palmitoyl-sn-glycero-3-phosphocholine on A2058 cell proliferation. Results showed no significant inhibition of cell proliferation.
Mar Drugs. 2020 Mar 17;18(3):166
A549 cells
3.13, 6.25, 12.5, 25, and 50 μg/mL
72 h
To test the effect of 1-palmitoyl-sn-glycero-3-phosphocholine on A549 cell proliferation. Results showed no significant inhibition of cell proliferation.
Mar Drugs. 2020 Mar 17;18(3):166
THP-1 cells
25 µg/mL and 50 µg/mL
6 h
To test the inhibitory effect of 1-palmitoyl-sn-glycero-3-phosphocholine on TNF-α release in LPS-stimulated THP-1 cells. Results showed significant inhibition of TNF-α release at 25 µg/mL and 50 µg/mL.
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