α-mangostin/α-倒捻子素
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货号：A161573
同义名：
alpha-Mangostin; NSC 27593
α-mangostin是一种膳食木酚素，具有广泛的生物活性，如抗氧化、抗过敏、抗病毒、抗细菌、抗炎和抗癌作用。它是突变IDH1（IDH1-R132H）的抑制剂，Ki值为2.85 μM。
α-mangostin/α-倒捻子素 化学结构
α-mangostin/α-倒捻子素 3D分子结构
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α-mangostin/α-倒捻子素 纯度/质量文件 产品仅供科研
货号：A161573
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α-mangostin/α-倒捻子素 质控信息
α-mangostin/α-倒捻子素 生物活性
描述
Alpha-mangostin, a natural xanthonoid, has antioxidant and anti-inflammatory properties. The IC50 values of α-mangostin in MCF-7 cells were 3.57 μM in 24 h and 2.74 μM in 48 h. As for MDA-MB-231 cells, the IC50 values were 3.35 μM in 24 h and 2.26 μM in 48 h. α-mangostin induced breast cancer cells apoptosis in a dose-dependent manner, reaching very high levels at 4 μM[3] In vitro , α-mangostin significantly reduced cell viability and induced apoptotic cell death. In addition, α-mangostin significantly disrupted the integrity of mitochondria measured by loss of MMP in a concentration-dependent manner[4]
α-mangostin/α-倒捻子素 参考文献
[1] Kim HJ, Fei X, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31.
[2] Li G, Petiwala SM, et al. Inhibition of CHOP accentuates the apoptotic effect of α-mangostin from the mangosteen fruit (Garcinia mangostana) in 22Rv1 prostate cancer cells. Biochem Biophys Res Commun. 2014 Oct 10;453(1):75-80.
[3] Li P, Tian W, Ma X. Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. Mol Cancer. 2014 Jun 3;13:138. doi: 10.1186/1476-4598-13-138. PMID: 24894151; PMCID: PMC4060095.
[4] Lee CH, Ying TH, Chiou HL, Hsieh SC, Wen SH, Chou RH, Hsieh YH. Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1/p38 signaling pathway in cervical cancer cells. Oncotarget. 2017 Jul 18;8(29):47425-47439. doi: 10.18632/oncotarget.17659. PMID: 28537893; PMCID: PMC5564576.
[5] Lee D, Kim YM, Jung K, Chin YW, Kang KS. Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage. Int J Mol Sci. 2018;19(5):1484. Published 2018 May 16.
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α-mangostin/α-倒捻子素 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.44mL
0.49mL
0.24mL
12.18mL
2.44mL
1.22mL
24.36mL
4.87mL
2.44mL
α-mangostin/α-倒捻子素 技术信息
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