Ambeed.cn

首页 / 抑制剂/激动剂 / / PAK

货号 产品名 纯度
A1177174 现货 GNE 2861

GNE 2861是一种选择性 PAK 抑制剂,特别对 II 类 PAKs 有效,抑制 PAK4, PAK5PAK6IC50 值分别为 7.5 nM, 36 nM 和 126 nM。

99%
A427173 现货 IPA-3

IPA-3是一种选择性的非ATP竞争性PAK1抑制剂,IC50为2.5 μM,对PAK组II(PAKs 4-6)无抑制作用。

99%+
A102618 现货 G-5555/G-5555游离态

G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM).

97%
A123005 现货 FRAX597

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).

99%+
A605423 现货 NVS-PAK1-1

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay.

99%+
A1220481 现货 LCH-7749944

LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity.

99%+
A225881 现货 FRAX486

FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM).

99%+
A1597312 现货 ZINC194100678

95%
A125108 现货 PF-3758309

PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.

99%+
A350879 现货 APTO-253

APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.

98%+
A1148024 现货 CFDA-SE/5(6)-羧基二乙酸荧光素琥珀酰亚胺酯(CFDASE )

CFSE is a fluorescent cell staining dye. CFSE is cell permeable and covalently couples, via its succinimidyl group, to intracellular molecules, notably, to intracellular lysine residues and other amine sources.

98% (mix)
A1148024 现货 CFDA-SE/5(6)-羧基二乙酸荧光素琥珀酰亚胺酯(CFDASE )

CFSE is a fluorescent cell staining dye. CFSE is cell permeable and covalently couples, via its succinimidyl group, to intracellular molecules, notably, to intracellular lysine residues and other amine sources.

98% (mix)
A1329217 现货 MYCMI-6

MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis .

99%+
A597098 现货 Padnarsertib

PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay.

99%+
A1268762 现货 Fingolimod-d4 HCl

98% 98%atom%D
A1595569 AZ13705339

98%
A1929245 st-Ht31

98%
A336531 PIR 3.5/双(6-羟基-2-萘)二硫

98%
A782450 Hydrastine/北美黄连碱

Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

98+%
A1552909 G-5555 HCl

98%
产品名 PAK PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 其他靶点 纯度
IPA-3 +

PAK1, IC50: 2.5 μM

+

PAK1, IC50: 2.5 μM

99%+
FRAX486 +++

PAK1, IC50: 14 nM

PAK4, IC50: 39 nM

+++

PAK1, IC50: 14 nM

++

PAK2, IC50: 33 nM

++

PAK3, IC50: 39 nM

+

PAK4, IC50: 575 nM

99%+
FRAX1036 ++

PAK2, Ki: 72.4 nM

PAK4, Ki: 23.3 nM

++

PAK1, Ki: 23.3 nM

++

PAK2, Ki: 72.4 nM

+

PAK4, Ki: 2.4 μM

98%+
FRAX597 ++++

PAK3, IC50: 13 nM

PAK2, IC50: 13 nM

++++

PAK1, IC50: 8 nM

++++

PAK2, IC50: 13 nM

+++

PAK3, IC50: 19 nM

99%+
PF-3758309 ++++

PAK3, IC50: 190 nM

PAK6, Ki: 17.1 nM

++++

PAK1, Ki: 13.7 nM

+

PAK2, IC50: 190 nM

++

PAK3, IC50: 99 nM

+++

PAK4, Ki: 18.7 nM

+++

PAK5, Ki: 18.1 nM

+++

PAK6, Ki: 17.1 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。