ZINC194100678是一种 PAK1 抑制剂，IC50 为 8.37 μM，可抑制 MDA-MB-231 细胞增殖，应用于抗癌研究。

GNE 2861是一种选择性 PAK 抑制剂，特别对 II 类 PAKs 有效，抑制 PAK4, PAK5 和 PAK6 的 IC50 值分别为 7.5 nM, 36 nM 和 126 nM。

G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM).

IPA-3是一种选择性的非ATP竞争性PAK1抑制剂，IC50为2.5 μM，对PAK组II（PAKs 4-6）无抑制作用。

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay.

PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.

LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity.

APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.

FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM).

MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis .

PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay.

Fingolimod-d4 HCl是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC₅₀ 为 0.033 nM。此外，Fingolimod 还可作为 pak1 激活剂，具有免疫抑制特性。

FRAX-1036 is a potent and selective PAK1 inhibitor.

CFDA-SE 是一种细胞示踪染料，通过与细胞内酯酶反应生成荧光产物。CFDA-SE 主要用于细胞增殖、迁移和追踪研究。

CFDA-SE 是一种细胞示踪染料，通过与细胞内酯酶反应生成荧光产物。CFDA-SE 主要用于细胞增殖、迁移和追踪研究。