IMR-1A is the metabolite of IMR-1, a Notch inhibitor targeting the transcriptional activation.

Medicarpin 是从苜蓿中分离出的黄酮类化合物。Medicarpin 通过调节 P-gp 介导的活性分子外排并克服多药耐药性，诱导白血病 P388 细胞凋亡。

RIN1 is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ. It also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling.

LY3039478 is a novel, potent Notch inhibitor with an IC50 of 0.41 nM.

ML414 (NGI-1) is an inhibitor of oligosaccharyltransferase (OST) with IC50 of 1.1 µM by targeting catalytic subunits STT3A and STT3B.

FLI-06 is a Notch signaling inhibitor with EC50 of 2.3 μM which can disrupt Notch trafficking and processing.

CB-103 is a first-in-class orally active pan-notch signaling pathway inhibitor extracted from patent US9296682B2 with anti-tumor activity.

Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.

DAPT (GSI-IX)是一种强效且具有口服活性的 γ-secretase 抑制剂，可用于细胞疗法中的辅助试剂。

ZLDI-8是一种Notch活化/裂解酶ADAM-17的抑制剂，能够抑制Notch蛋白的裂解，并降低与细胞存活、抗凋亡及上皮-间质转化相关蛋白的表达。ZLDI-8 还作为一种竞争性且不可逆的酪氨酸磷酸酶(Lyp)抑制剂（IC₅₀=31.6 μM，Ki=26.22 μM），对MHCC97-H细胞生长的IC₅₀为5.32 μM。

LY-411575是一种高效的 γ-分泌酶抑制剂，其 IC50 值分别为 0.078 nM 和 0.082 nM（膜/细胞基质），并且还以 IC50 为 0.39 nM 抑制 Notch S3 切割。

Bruceine D 是一种 Notch 抑制剂，具有抗癌活性，可在多个人类癌细胞系中诱导凋亡。Bruceine D 对 D. intermedius 显示出强效的杀虫活性，其 EC50 值为 0.57 mg/L。

SAHM1 is a stabilized hydrocarbon-stapled alpha helical peptide targeting Notch pathway. It mimics a dominant negative form of MAML, inhibits canonical Notch transcription complex formation.