Ambeed.cn

首页 / 抑制剂/激动剂 / 免疫/炎症 / IRAK

货号 产品名 纯度
A1157106 现货 AZ1495

AZ1495 是一种弱碱性、口服活性有效的白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂。AZ1495 对 IRAK4 和 IRAK1 具有良好的物理化学和激酶选择性,IC50 值分别为 0.005 μM 和 0.023 μM。

97%
A567818 现货 Zimlovisertib

Zimlovisertib (PF-06650833)一种有效、选择性且口服可利用的白介素-1 受体相关激酶 4 (IRAK4) 抑制剂,IC50 为 0.2 nM,在 PBMC 测试中的 IC50 为 2.4 nM,研究领域包括类风湿性关节炎、狼疮和淋巴瘤。

97%
A356366 现货 IRAK inhibitor 1

IRAK 抑制剂 1 是一种有效的 IRAK-4 抑制剂,IC50 为 216 nM,同时对 JNK-1 和 JNK-2 的抑制作用较弱,IC50 值分别为 3.801 μM 和 >10 μM。

98%
A1956667 现货 JNJ-1013

JNJ-1013是一种有效的选择性IRAK1降解剂,其对IRAK1、IRAK4和VHL FP的IC50值分别为72 nM、443 nM和1071 nM。JNJ-1013诱导凋亡,增加裂解的PARP表达,同时降低IRAK1、p-IKBα和pSTAT3(Tyr705)的表达。

98%
A423092 现货 APY0201

APY0201 是一种强效、高选择性的 ATP 竞争性 PIKfyve 抑制剂(IC50 = 5.2 nM),可阻断磷脂酰肌醇 3-磷酸(PtdIns3P)向 PtdIns(3,5)P2 的转化。同时,它抑制小分子 IL-12/23 的产生。

98%
A709320 现货 IRAK4-IN-1

98%
A414161 现货 IRAK inhibitor 2

IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .

98%
A345196 现货 IRAK4-IN-7

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models

99%+
A805441 现货 AS2444697

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 21 nM.

98%
A1598756 现货 HS-243

95%
A1216693 现货 IRAK4-IN-4

IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

99%+
A927418 现货 IRAK-4 protein kinase inhibitor 2

99%+
A1964207 现货 Larotinib

98%+
A1388394 现货 Zabedosertib

99%+
A1545166 现货 IRAK4-IN-20

99%
A1487545 现货 JH-X-119-01

Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor.

98%+
A1671259 现货 KT-474

98%
A1152397 现货 Emavusertib

CA-4948 is a selective and orally bioavailable IRAK4 Inhibitor. It exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.

99%+
A496272 现货 IRAK-1-4 Inhibitor I/IRAK1 / 4抑制剂I

IRAK-1-4 Inhibitor I is a IRAK-4 inhibitor with IC50 of 200 nM.

99%+
A359407 现货 Anthraquinone-2-carboxylic acid/蒽醌-2-羧酸

Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of fruits and herbs.

95%
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。