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货号 产品名 纯度
A1483455 PR5-LL-CM01

98%+
A1603652 Tulmimetostat

Tulmimetostat(CPI-0209)是一种口服活性的EZH1/EZH2抑制剂,具有抗肿瘤活性,用于各种实体瘤的研究。

98%
A1673640 EZH2-IN-13

98%
A1953384 PRMT4-IN-1

98%
A339740 Metoprine

98%
A391113 AZ505 ditrifluoroacetate

AZ505 ditrifluoroacetate selectively inhibits SMYD2 with IC50 of 0.12 μM.

99%+
A567534 MS049

MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively.

98%+
A921258 JQEZ5

JQEZ5 is a potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor with IC50 of 11 nM.

99%+
A896158 TP-064

TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM.

99%+
A155170 XY1

XY1 is a negative control of SGC 707 which works as a potent and selective allosteric inhibitor of PRMT3, while XY1 shows almost no activity.

99%+
A169549 TC-E 5003

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.

99%+
A165657 SGC707

SGC707 is a chemical probe of PRMT3 with IC50 of 31 nM.

99%+
A580882 BAY-598

BAY-598 is an inhibitor of SMYD2. It can inhibit in vitro methylation of p53 at lysine 370 with IC50 value of 27 nM.

99%+
A713137 Sinefungin

Sinefungin is an inhibitor of Zika virus methyltransferase.

99%+
A720833 HLCL-61 HCl/HLCL-61盐酸盐

HLCL-61 HCl is an inhibitor of PRMT5 that is used for the treatment of acute myeloid leukemia.

98%
A1364995 VTP50469

VTP-50469 is a novel, potent, selective, orally-available MeninMLL1 inhibitor, being effectively against MLL-rearranged and NPM1c+ leukemia, selectively killing cell lines with MLLrearrangements and NPM1c+ mutations.

99%+
A912563 GSK2807 Trifluoroacetate

GSK2807 Trifluoroacetate is a SMYD3 SAM-competitive inhibitor with Ki of 14 nM.

99%+
A550753 AZ505

AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2 (IC50=0.12 μM) with potential anticancer activity, > 600 fold than SMYD3 (IC50> 83.3 μM), DOT1L (IC50> 83.3 μM), EZH2 (IC50> 83.3 μM).

99%+
A651436 WDR5-0103

WDR5-0103 is a selective antagonist of WD repeat-containing protein 5 (WDR5) with Kd of 450 nM.

99%+
A718589 UNC3866

UNC3866 is a high-affinity CBX4 and CBX7 inhibitor with Ki values of 94 and 97 nM, respectively.

99%+
产品名 Histone Methyltransferase 其他靶点 纯度
BRD4770 99%+
UNC1999 +++

EZH1, IC50: 45 nM

EZH2, IC50: 2 nM

99%+
EPZ005687 ++

EZH2, Ki: 24 nM

99%+
EPZ015666 +++

PRMT5, Ki: 5 nM

99%+
3-Deazaneplanocin A HCl ++++

S-adenosylhomocysteine hydrolase, Ki: 50 pM

99%+
EPZ6438 +++

EZH2, IC50: 11 nM

EZH2, Ki: 2.5 nM

98%
GSK126 ++

EZH2, IC50: 9.9 nM

99%+
MI-3 +

Menin-MLL, IC50: 648 nM

98%
MM-102 ++

MLL1, IC50: 0.4 μM

99%
EI1 ++

Ezh2 (wild-type), IC50: 15 nM

EZH2 (Y641F), IC50: 13 nM

99%+
SGC0946 ++++

DOT1L, IC50: 0.3 nM

99%+
PFI-2 HCl ++++

SETD7, IC50: 2 nM

SETD7, Ki: 0.33 nM

99%+
Pinometostat ++++

DOT1L, Ki: 80 pM

99%+
EPZ004777 +++

DOT1L, IC50: 0.4 nM

99%+
Entacapone ++

COMT, IC50: 151 nM

95%
UNC0379 +

SETD8, IC50: 7.9 μM

99%+
Menin-MLL inhibitor MI-2 +

Menin-MLL, IC50: 446 nM

98%
GSK343 +++

EZH1, IC50: 240 nM

EZH2, IC50: 4 nM

99%+
BIX-01294 3HCl +

G9a, IC50: 2.7 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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