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货号 产品名 纯度
A603143 现货 Vismodegib/维莫德吉

Vismodegib(GDC-0449)是一种口服活性的Hedgehog通路抑制剂,IC50为3 nM。Vismodegib还抑制P-gp和ABCG2,其IC50值分别为3.0 μM和1.4 μM。

98%
A1209303 现货 Neurodazine

Neurodazine是一种神经生成诱导剂,通过激活 Wnt 和 Shh 信号通路促进多能细胞的神经生成。

98%
A1155088 现货 Hh-Ag1.5

97%
A1364787 现货 Ciliobrevin D

98%
A139966 现货 Veratramine/黎芦碱

Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine.

98%
A628488 现货 20(S)-Hydroxycholesterol

20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells.

98%+
A378069 现货 SANT-1

SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM).

99%+
A162607 现货 Mebendazole/甲苯咪唑

Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations.

97%
A1281358 现货 RL-0070933

98%+
A450950 现货 SMANT hydrochloride

97%
A706302 现货 JK184

JK184 is a hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.

95%
A758319 现货 AY 9944

AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling.

99%+
A810470 现货 SANT-2

Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity

99%+
A765852 现货 GGTI-2418

GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1].

98%+
A1374226 现货 Lactoferrin (17-41) (acetate)

99%
A1209852 Robotnikinin

97%
A1671304 RUSKI-201 2HCl

98%
A2250226 Hedgehog IN-3

98%
A2261945 Hedgehog IN-5

98%
A2250215 Hedgehog IN-2

98%
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