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货号 产品名 纯度
A742025 SU6656/2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基] -1H-吲哚-5-磺酰胺

SU 6656 is an inhibitor of Src kinases and can target Src, Yes, Lyn, and Fyn with IC50 of 280 nM, 20 nM, 130 nM, 170 nM, respectively.

99%+
A1598840 FAK-IN-7

95%
A1598863 FAK-IN-10

95%
A640498 Batatasin III/山药素Ⅲ

97%
A318281 GSK2256098

GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

99%+
A103079 PND-1186

PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.

99%+
A325541 PF-431396

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.

99%+
A230913 PF-573228

PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM.

99%+
A740806 Defactinib HCl

Defactinib HCl is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.

99%+
A554072 PF-562271 besylate/PF 562271 苯磺酸盐

PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.

99%+
A1535395 Narmafotinib

95%
A143423 Defactinib/地法替尼

Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.

99%+
A191099 Y15

Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.

97%
A1601210 YH-306

98%+
A301515 PF-562271

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.

99%+
A134996 Masitinib/马赛替尼

Masitinib is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms.

99%+
A121000 NVP-TAE 226

NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

99%+
A334684 Fangchinoline/防己诺林碱

Fangchinoline is an isolate of Stephania tetrandra and has anticancer activity through induction of G1 arrest in breast cancer cells.

98%
A173517 CTX-0294885

CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.

99%+
A1364798 FAK inhibitor 2

98%
产品名 FAK 其他靶点 纯度
Defactinib 99%+
NVP-TAE 226 ++

FAK, IC50: 5.5 nM

PYK2, IC50: 3.5 nM

Insulin Receptor,IGF-1R 99%+
PF-573228 +

FAK, IC50: 4 nM

99%+
Solanesol 98%
PF-431396 ++

FAK, IC50: 2 nM

PYK2, IC50: 11 nM

99%+
PND-1186 ++++

FAK, IC50: 1.5 nM

99%+
PF-562271 ++++

FAK, IC50: 1.5 nM

PYK2, IC50: 13 nM

99%+
GSK2256098 ++++

FAK, Ki: 0.4 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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