PF-573228是一种强效且选择性的 FAK 抑制剂，对纯化的重组 FAK 催化片段的 IC50 为 4 nM。

Defactinib HCl (VS-6063 hydrochloride; PF 04554878 hydrochloride)以时间和剂量依赖方式抑制FAK在Tyr397位点的磷酸化。

PF-562271 besylate (VS-6062) 苯磺酸盐是一种高效的 ATP 竞争性、可逆性 FAK 和 Pyk2 激酶抑制剂，对 FAK 的 IC50 为 1.5 nM，对 Pyk2 的 IC50 为 13 nM。

Narmafotinib（AMP-945）是一种针对黏着斑激酶（FAK）的抑制剂，其KD为0.21 nM。Narmafotinib在MDA-MB-231细胞中抑制了397Y-FAK的自磷酸化，IC50为7 nM，并且表现出低细胞毒性（IC50 = 2.7 μM，MDA-MB-231细胞）。

Defactinib（VS-6063；PF-04554878）是一种新型FAK抑制剂，表现出潜在的抗血管生成和抗肿瘤特性。

PF-562271（VS-6062）是一种高效、ATP竞争性和可逆的FAK和Pyk2激酶抑制剂，IC50值分别为1.5 nM和13 nM。

CEP-37440 is a potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma).

GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.

Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.

Masitinib is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms.

NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

Fangchinoline is an isolate of Stephania tetrandra and has anticancer activity through induction of G1 arrest in breast cancer cells.