LIT-927 是局部的、有口服活性的 CXC 趋化因子12 (CXCL12) 的中性配体，具有抗炎作用，对 CXCL12 结合到其受体 CXCR4 的 Ki 值为 267 nM。

MSX-122 是一种口服可用的部分 CXCR4 拮抗剂，抑制 CXCR4/CXCL12 相互作用的 IC50 约为 10 nM。MSX-122 具有抗炎和抗转移活性。

Decursin ((+)-Decursin) 是一种有效的抗癌剂，具有细胞毒性和强效激活蛋白激酶 C (PKC) 的作用。Decursin 诱导细胞凋亡和 G1 期细胞周期停滞。Decursin 在 48 小时内减少 CDK2、CDK4、CDK6 和 cyclin D1 蛋白的表达。Decursin 抑制细胞增殖和迁移，具有抗肿瘤、抗炎和镇痛活性。

AZD8797（KAND567）是一种别构、非竞争性、口服有效的人CX3CR1受体拮抗剂，对CX3CR1和CXCR2的Ki值分别为3.9 nM和2800 nM。

Reparixin是一种非竞争性变构CXCR1和CXCR2激活抑制剂，其IC50分别为1 nM和100 nM。

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.

AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.

USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].

NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.

SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.

ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.

SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.

UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 17.9 μM for 9 cancer cell lines.

Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.

Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals.

SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing > 150-fold selectivity over CXCR1 and four other 7-TMRs.