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货号 产品名 纯度
A1251826 VUF11207 fumarate

98%
A914195 LIT-927

LIT-927 is a neutraligand of CXCL12 (Ki= 267 nM) with anti-inflammatory effect and it has a high binding selectivity for CXCL12 over other chemokines

98%
A278381 JMS-17-2

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.

97%
A105208 AMD-070 hydrochloride

AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.

99%+
A790755 AMD 3465 6HBr

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

98%
A1001764 USL311

USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].

99%+
A909799 Decursin/紫花前胡素

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2.

99%+
A592527 ZK 756326

ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.

99%+
A468366 NBI-74330

NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.

98%+
A220173 WZ811

WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.

98%
A477793 SRT3109

SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.

99%+
A427101 AMG 487

AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.

99%+
A409872 ATI-2341/ATI-2341 三氟乙酸

ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.

98%
A893890 UNBS5162

UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 17.9 μM for 9 cancer cell lines.

99%+
A114553 Baohuoside I/宝藿苷 I

Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.

98%
A1365951 PS372424 HCl

98%+
A1396274 CXCR2 antagonist 8

97%
A1495158 Tannic acid/单宁酸

Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals.

95%
A413083 Motixafortide/莫替昔福特 (三氟乙酸盐)

BKT140 is a CXCR4 antagonist with an IC50 value of ~1 nM.

99%
A912137 MSX-122

MSX-122 is a small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM).

98%
产品名 CXCR1 CXCR2 CXCR4 其他靶点 纯度
Reparixin 99%+
SB225002 +++

CXCR2, IC50: 22 nM

99%+
Plerixafor ++

CXCR4, IC50: 44 nM

99%
AMD 3465 6HBr 98%
WZ811 ++++

CXCR4, EC50: 0.3 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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