Opicapone is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

Entacapone sodium is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Entacapone is a specific, potent and peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Flopropione is both a 5-HT1A receptor antagonist and a COMT inhibitor as a spasmolytic or antispasmodic agent.

Tolcapone is a potent, selective and orally active catechol-O-methyltransferase (COMT) inhibitor with Ki of 30 nM.

HBX 41108 是一种非竞争性泛素特异性蛋白酶 7（USP7）抑制剂，IC50 为 424 nM。HBX 41108 抑制 USP7 介导的 p53 去泛素化，从而稳定 p53 并抑制癌细胞生长。HBX 41108 诱导 p53 依赖的凋亡。