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首页 / 抑制剂/激动剂 / 蛋白质酪氨酸激酶(Protein Tyrosine Kinase) / TAM受体

货号 产品名 纯度
A171244 现货 Bemcentinib/贝森替尼

Bemcentinib(R428) GMP 是一种口服活性和选择性的 Axl 抑制剂,IC50 为 14 nM。

99%+
A212266 现货 Cabozantinib S-malate/卡博替尼苹果酸盐

Cabozantinib S-malate (XL184 S-malate) 是一种多受体酪氨酸激酶的强效抑制剂,包括 VEGFR2、c-Met、Kit、Axl 和 Flt3IC50 值分别为 0.035、1.3、4.6、7 和 11.3 nM。

99+%
A425350 现货 Gilteritinib/吉列替尼

Gilteritinib (ASP2215) 是一种强效和 ATP 竞争性的 FLT3/AXL 抑制剂,IC50 值分别为 0.29 nM 和 0.73 nM。

99%+
A1177155 现货 UNC2541

98%
A202271 现货 UNC2250

UNC2250 is an inhibitor of Mer with IC50 of 1.7 nM.

99%+
A386651 现货 LDC1267

LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of < 5 nM, 8 nM, 29 nM, respectively.

99%+
A1258381 现货 Tamnorzatinib

ONO-7475 is a potent and selective inhibitor of active novel Axl/Mer tyrosine kinase with IC50 values of 0.7nM and 1nM, respectively. It potently arrested growth and induced apoptosis in acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3.

99%+
A1537879 现货 FEN1-IN-SC13

SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model.

98%+
A518169 现货 NPS-1034

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.

99%+
A771421 现货 SGI-7079

SGI-7079, a selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.

99%+
A214490 现货 UNC2881

UNC2881 is a Mer kinase inhibitor and can inhibit the phosphorylation of Mer with IC50 of 4.3 nM.

99%+
A525104 现货 CEP-40783

RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells.

99%+
A173278 现货 Dubermatinib/杜贝马丁尼(TP-0903)

TP-0903 is a selective Axl kinase inhibitor with IC50 of 27 nM.

99%+
A756664 现货 BMS 777607

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, being 40-fold selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

99%+
A1364788 RU-302

98%
A1601519 Axl-IN-4

98%
A1673117 TL4830031

98%
A1671807 Axl-IN-11

98%
A708914 UNC1062

99+%
A1081347 RU-301

95%
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