Ro 5212773 (EPPTB)是一种高效且选择性的痕胺相关受体 1 (TAAR1) 拮抗剂，对小鼠 TAAR1 的 Ki 值为 0.9 nM，且对其他 TAAR 受体无显著影响。

RO5166017是一种具有跨物种活性的 TAAR1 激动剂，口服生物利用度高。在小鼠、大鼠、人和食蟹猴中的 Ki 值分别为1.9 nM、2.7 nM、31 nM 和 24 nM，适用于中枢神经系统相关疾病的研究。

RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition and shows antidepressant-like effect[1][2][3].

Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).

RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines. RO5256390 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties.

SEP-363856 （SEP-856）, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 （SEP-856） has the potential for the treatment of schizophrenia[1].