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全部(106) Agonist(4) Antagonist(1) Inhibitor(8) Activator(6)
STING-IN-3是一种STING抑制剂,通过靶向STING的跨膜半胱氨酸残基来阻断STING信号通路,适用于研究免疫相关疾病。
STING-IN-2是一种有效且共价的STING抑制剂,能够抑制小鼠和人类STING,适用于自身炎症性疾病的研究。
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity .
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CCCP can inhibit the activation of STING and is widely used as a protonophore uncoupling agent for oxidative phosphorylation. CCCP is the most commonly used inducer of mitophagy in mammalian cells and is thought to exert its effects by reducing the mitochondrial membrane potential.
C-178 is a STING inhibitor that can block palmitoylation (PMA)-induced clustering of STING.
C-176 is a STING inhibitor with anti-inflammatory effection.
DUN99845 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease.
STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses.
STING agonist-3 is a selective small-molecule STING agonist which has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
ChX710 can boost cellular response to cytosolic DNA via STING. It efficiently primed cellular response to transfected plasmid DNA as assessed by potent synergistic effects on IFN-β secretion and ISG expression levels.
1-(4-Ethylphenyl)-3-(1H-indol-3-yl)urea, also known as H-151, is a irreversible inhibitor of STING that can inhibit the type I interferon (IFN) response and reduce the phosphorylation of TBK1 and palmitoylation of human STING in vitro.
ADU-S100 disodium salt是一种 STING 激活剂,展示出显著的抗肿瘤和免疫调节活性,适用于癌症免疫治疗研究。
SN-011 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. SN-011 is a demethyl analogue of DUN99845.
BTR-1 is a rhodanine derivative induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, leading to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.
NVS-STG2是一种靶向STING的分子胶,能够激活STING介导的免疫信号。
MSA-2是一种 STING 激动剂,具有抗肿瘤活性,并可能与抗 PD-1 治疗联合使用。
diABZI STING agonist-1 is a selective STING receptor agonist with EC50 value of 130nM.
Tags: STING | 免疫/炎症 | Immunology/Inflammation | 帕金森与阿尔茨海默症 | Parkinson's disease and Alzheimer's disease | 肿瘤发展和微环境演变 | Tumor Development and Microenvironment Evolution | STING 相关产品
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