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ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells.
PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM.
K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
SKI-178 is an in vivo active non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM), which induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines.
Tags: SphK | 免疫/炎症 | Immunology/Inflammation | 自噬 | Autophagy | SphK 相关产品
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