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货号 产品名 纯度
A245799 现货 Ipragliflozin (L-Proline)

Ipragliflozin (L-Proline) selectively inhibits SGLT2 with IC50 of 2.8 nM.

98%
A297470 现货 Remogliflozin etabonate

Remogliflozin etabonate(GSK189075)是一种口服活性、选择性和低亲和力的钠-葡萄糖共转运蛋白SGLT2)抑制剂,其对hSGLT2、rSGLT2、hSGLT1和rSGLT1的Ki值分别为1.95 μM、43.1 μM、2.14 μM和8.57 μM。

97%
A145381 现货 Dapagliflozin impurity/达格列净杂质

Dapagliflozin impurity是 Dapagliflozin 的对映异构体,Dapagliflozin是一种钠葡萄糖共转运蛋白 2 (SGLT2) 抑制剂。

99%+
A1167800 现货 Mizagliflozin

Mizagliflozin是一种高效的 SGLT1 抑制剂,通过抑制小肠中的钠-葡萄糖共转运蛋白,改善餐后血糖水平,并有助于慢性便秘的治疗。它在糖尿病和胃肠道疾病的研究中具有应用前景。

98%
A1339527 现货 KGA-2727

KGA-2727是一种选择性高且口服活性的 SGLT1 抑制剂,具有显著的高亲和力。它对 SGLT1 的选择性远高于 SGLT2,并在抗糖尿病治疗中显示出显著效果。

98%
A136380 现货 Ipragliflozin/伊格列净

Ipragliflozin is a selective inhibitor of SGLT2 with IC50 of 14 nM for hSGLT2.

98%
A225622 现货 Sotagliflozin

LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity.

98%
A1006406 现货 Ertugliflozin L-pyroglutamic acid

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

99%
A671271 现货 Trilobatin/三叶甙

Trilobatin, a natural product isolated and purified from the herbs of Lithocarpus pachyphyllus with anti-oxidant effect, potentially inhibits the LPS-induced inflammatory response by suppressing the NF-κB signaling pathway and is a potential effective α-glucosidase inhibitor for management of postprandial hyperglycemia with less side effect.

99%+
A191432 现货 Ertugliflozin/埃格列净

PF-04971729 is a selective sodium-dependent glucose cotransporter (SGLT) inhibitor which selectively targets SGLT2.

98%
A112500 现货 Empagliflozin/恩格列净

Empagliflozin (BI 107730) 是一种选择性钠-葡萄糖协同转运蛋白-2(SGLT-2)抑制剂,对人类SGLT-2的IC50为3.1 nM。

98%
A247239 现货 Canagliflozin hemihydrate/坎格列净半水合物

Canagliflozin hemihydrate (JNJ28431754 hemihydrate) 是一种选择性的SGLT2抑制剂,在CHOK细胞中对mSGLT2、rSGLT2和hSGLT2IC50值分别为2 nM、3.7 Nm和4.4 Nm。

98%
A335983 现货 Canagliflozin/卡格列净

Canagliflozin (JNJ 28431754)是一种选择性SGLT2抑制剂,其在CHOK细胞中对mSGLT2、rSGLT2和hSGLT2IC50值分别为2 nM、3.7 nM和4.4 nM。

95%
A163609 现货 Phlorizin/根皮苷

Phlorizin is an inhibitor of hSGLT1 (Ki=300 nM) and hSGLT2 (Ki= 39 nM). It can be found in a number of fruit trees.

98%
A170374 现货 Phloretin/根皮素

Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree.

98%
A566836 现货 Tofogliflozin (hydrate)

Tofogliflozin hydrate (CSG-452 hydrate)是一种高效、特异性和选择性的 SGLT2 抑制剂。IC50 值为 2.9 nM(人),14.9 nM(大鼠),6.4 nM(小鼠),部分抑制高糖诱导的肾小管细胞 ROS 生成。

99%+
A120381 现货 Dapagliflozin/达格列净

Dapagliflozin(BMS-512148)是一种治疗糖尿病的新药,是一种竞争性钠/葡萄糖协同转运蛋白2(SGLT2)抑制剂,导致尿中葡萄糖排泄。Dapagliflozin诱导HIF1表达并减少肾缺血再灌注损伤。

97%
A237947 现货 Licogliflozin

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor

98%+
A187149 现货 Bexagliflozin

Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM.

99%+
A1231619 现货 O-Desethyl Dapagliflozin

O-Desethyl Dapagliflozin是一种 SGLT2 抑制剂

95%
产品名 SGLT1 SGLT2 其他靶点 纯度
Phloretin 98%
Canagliflozin +++

mSGLT2, IC50: 2 nM

hSGLT2, IC50: 3.7 nM

95%
Empagliflozin ++

SGLT2, IC50: 3.1 nM

98%
Dapagliflozin ++++

hSGLT2, EC50: 1.1 nM

97%
Tofogliflozin (hydrate) +++

hSGLT2, IC50: 2.9 nM

99%+
Sotagliflozin +

SGLT1, IC50: 36 nM

++++

SGLT2, IC50: 1.8 nM

98%
Ipragliflozin ++

hSGLT2, IC50: 7.4 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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