To evaluate the effect of epiberberine on the migration and invasion of FaDu cells. Results showed that epiberberine significantly inhibited cell migration and invasion in a dose-dependent manner.
J Cell Mol Med. 2023 Dec;27(23):3796-3804
Ca9-22 cells
10, 20, 40 μM
24 hours
To evaluate the effect of epiberberine on the migration and invasion of Ca9-22 cells. Results showed that epiberberine significantly inhibited cell migration and invasion in a dose-dependent manner.
J Cell Mol Med. 2023 Dec;27(23):3796-3804
rat liver microsomes
2.5, 5, 10, 20 μM
120 minutes
Evaluate the inhibitory properties of EPI on CYP2D6, results showed that EPI had obvious noncompetitive inhibitory effects on CYP2D6
Drug Des Devel Ther. 2017 Dec 28;12:57-65
human liver microsomes
2.5, 5, 10, 20 μM
120 minutes
Evaluate the inhibitory properties of EPI on CYP2C9 and CYP2D6, results showed that EPI had obvious noncompetitive inhibitory effects on CYP2C9 and CYP2D6
Drug Des Devel Ther. 2017 Dec 28;12:57-65
epiberberine/表小檗碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague Dawley rats
Normal rats
Oral
10, 54, 81 mg/kg
Single dose
Evaluate the pharmacokinetics and oral bioavailability of EPI in rats, results showed that EPI was rapidly absorbed and metabolized, with Tmax of 0.37–0.42 h, T1/2 of 0.49–2.73 h, and oral absolute bioavailability of 14.46%
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