There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Warfarin sodium is a medication that is used as a blood thinner by blocking an enzyme called vitamin K epoxide reductase that reactivates vitamin K1.
Warfarin sodium/华法林钠 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Jugular vein cannulation model
Intravenous injection
1 mg/kg
Single dose, up to 144 hours
To evaluate the effect of etravirine on the pharmacokinetics and blood clotting time of warfarin. Results showed that etravirine significantly increased the systemic clearance and volume of distribution of S-warfarin but not R-warfarin. Etravirine also potentiated the anticoagulant effect of warfarin (INR values significantly increased).
Br J Pharmacol. 2013 Apr;168(8):1851-8
Rats
Cerulein-induced acute pancreatitis model
Intragastric administration
90, 180, or 270 µg/kg/dose
Once daily for 7 consecutive days
Pretreatment with warfarin inhibited the development of cerulein-induced acute pancreatitis, reduced histological signs of pancreatic damage, decreased the increase in serum lipase and amylase activity, reduced plasma D-dimer and interleukin-1β concentrations, and improved pancreatic blood flow.
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