Valacyclovir Hydrochloride is the hydrochloride salt of valacyclovir. Valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication. It is used in the management of herpes simplex and varicella zoster infections, as well as prophylactically for human cytomegalovirus infections[3]. Valacyclovir is safe and effective in the therapy of patients with herpes simplex and herpes zoster and may be useful in other viral infections[4]. Valacyclovir has similar efficacy to acyclovir in the episodic and suppressive treatment of genital herpes. In addition, valacyclovir is also indicated in the reduction of the sexual transmission of herpes simplex virus infection and for the treatment of herpes labialis. In herpes zoster, valacyclovir is more effective than acyclovir or placebo (and as equally effective as famciclovir) in shortening the length and severity of herpes zoster-associated pain and postherpetic neuralgia. Valacyclovir has an acceptable safety profile in patients with herpes simplex and herpes zoster[5]. Nucleoside analogues against herpes simplex virus (HSV) have been shown to suppress shedding of HSV type 2 (HSV-2) on genital mucosal surfaces and may prevent sexual transmission of HSV. Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2-discordant couples[6].
United States, Pennsylvania
... 展开 >>
University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Brenda Horn 215-590-4202 brenda.horn@uphs.upenn.edu
Principal Investigator: Sunil Singhal 收起 <<
United States, Pennsylvania
... 展开 >>
University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Brenda Horn 215-590-4202 brenda.horn@uphs.upenn.edu
Principal Investigator: Sunil Singhal 收起 <<
United States, Michigan
... 展开 >>
Wayne State University
Detroit, Michigan, United States, 48201
United States, Pennsylvania
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213 收起 <<
United States, Texas
... 展开 >>
Houston Methodist Neurological Institute
Recruiting
Houston, Texas, United States, 77030
Contact: David S. Baskin, MD 713-441-3800 DBaskin@houstonmethodist.org
Contact: Helga M. Jones 713-363-9388 HMJones@houstonmethodist.org 收起 <<
United States, Indiana
... 展开 >>
Indiana University School of Medicine, IU Infectious Diseases Research
Indianapolis, Indiana, United States, 46202
United States, Oregon
Westover Heights Clinic
Portland, Oregon, United States, 97210
United States, Texas
University of Texas Health Science Centre, Center for Clincial Studies
Houston, Texas, United States, 77030
United States, Washington
University of Washington, Virology Research Clinic
Seattle, Washington, United States, 98104 收起 <<
United States, California
... 展开 >>
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010-3000
Stanford Cancer Center at Stanford University Medical Center
Stanford, California, United States, 94305
United States, Nebraska
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-3330
United States, Texas
Baylor University Medical Center
Dallas, Texas, United States, 75246
United States, Utah
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84132
United States, Washington
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-1024 收起 <<
Metastatic Non-small Cell Lung... 展开 >> Cancer
Metastatic Triple-negative Breast Cancer 收起 <<
Phase 2
Recruiting
November 2023
United States, Texas
... 展开 >>
Houston Methodist Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Jenny C Chang, MD 713-441-0629 ccresearch@houstonmethodist.org 收起 <<
Canada, British Columbia
... 展开 >>
Eric Martin Pavilion
Victoria, British Columbia, Canada
Peace Arch Hospital
White Rock, British Columbia, Canada 收起 <<
United States, California
... 展开 >>
ARYS-0701 Site 3
Beverly Hills, California, United States, 90211
ARYS-0701 Site 6
Encino, California, United States, 91436
ARYS-0701 Site 7
Vista, California, United States, 92083
United States, Nevada
ARYS-0701 Site 8
Henderson, Nevada, United States, 89014
ARYS-0701 Site 9
Las Vegas, Nevada, United States, 89106
United States, New York
ARYS-0701 Site 10
New York, New York, United States, 10003
ARYS-0701 Site 11
New York, New York, United States, 10029
ARYS-0701 Site 4
New York, New York, United States, 10032
United States, North Carolina
ARYS-0701 Site 12
Raleigh, North Carolina, United States, 27612
United States, Texas
ARYS-0701 Site 1
Houston, Texas, United States, 77058 收起 <<
United States, Colorado
... 展开 >>
GSK Investigational Site
Denver, Colorado, United States, 80204
United States, Florida
GSK Investigational Site
Altamonte Springs, Florida, United States, 32701
GSK Investigational Site
Fort Myers, Florida, United States, 33901
United States, Illinois
GSK Investigational Site
Chicago, Illinois, United States, 60657
United States, Massachusetts
GSK Investigational Site
Boston, Massachusetts, United States, 02115
United States, New Jersey
GSK Investigational Site
Voorhees, New Jersey, United States, 08043
United States, New York
GSK Investigational Site
Rochester, New York, United States, 14604
United States, South Carolina
GSK Investigational Site
Columbia, South Carolina, United States, 29206-4713
United States, Texas
GSK Investigational Site
Dallas, Texas, United States, 75246
GSK Investigational Site
Fort Worth, Texas, United States, 76104
Australia, New South Wales
GSK Investigational Site
Darlinghurst, New South Wales, Australia, 2010
Hong Kong
GSK Investigational Site
Kowloon Bay, Hong Kong 收起 <<
Glioblastoma Multiforme
... 展开 >> Astrocytoma, Grade III 收起 <<
Phase 1
Phase 2
Recruiting
December 30, 2025
United States, Texas
... 展开 >>
Houston Methodist Neurological Institute
Recruiting
Houston, Texas, United States, 77030
Contact: David S Baskin, MD 713-441-3800 DBaskin@houstonmethodist.org
Contact: Helga M Jones 713-363-9388 HMJones@houstonmethodist.org 收起 <<
United States, California
... 展开 >>
City of Hope Medical Center
Duarte, California, United States, 91010
United States, Illinois
The University of Chicago
Chicago, Illinois, United States, 60637
United States, Ohio
The Ohio State University Medical Center, Dept. Neurological Surgery
Columbus, Ohio, United States, 43210
United States, Texas
The Methodist Hospital Neurological Institute
Houston, Texas, United States, 77030 收起 <<
United States, Florida
... 展开 >>
Daytona Beach, Florida, United States, 32117
United States, Hawaii
Honolulu, Hawaii, United States, 96813
United States, Indiana
Evansville, Indiana, United States, 47710
United States, Texas
Austin, Texas, United States, 78752
Dallas, Texas, United States, 75247 收起 <<
United States, Ohio
... 展开 >>
The Ohio State University Medical Center, Dept Neurosurgery
Columbus, Ohio, United States, 43210
United States, Texas
The Methodist Hosptial
Houston, Texas, United States, 77030 收起 <<
United States, California
... 展开 >>
GSK Investigational Site
Anaheim, California, United States, 92805
GSK Investigational Site
Carmichael, California, United States, 95608
GSK Investigational Site
Fair Oaks, California, United States, 95628
GSK Investigational Site
Sacramento, California, United States, 95816
GSK Investigational Site
San Diego, California, United States, 92123
United States, Florida
GSK Investigational Site
Boynton Beach, Florida, United States, 33437
GSK Investigational Site
Saint Petersburg, Florida, United States, 33710
United States, Indiana
GSK Investigational Site
Indianapolis, Indiana, United States, 46202
GSK Investigational Site
South Bend, Indiana, United States, 46601
United States, Michigan
GSK Investigational Site
Portage, Michigan, United States, 49024
United States, New York
GSK Investigational Site
New York, New York, United States, 10029
United States, North Carolina
GSK Investigational Site
Chapel Hill, North Carolina, United States, 27599
GSK Investigational Site
Winston-Salem, North Carolina, United States, 27103
United States, Oklahoma
GSK Investigational Site
Tulsa, Oklahoma, United States, 74104
United States, Oregon
GSK Investigational Site
Portland, Oregon, United States, 97210
United States, Pennsylvania
GSK Investigational Site
Philadelphia, Pennsylvania, United States, 19140
United States, Tennessee
GSK Investigational Site
Memphis, Tennessee, United States, 38104
GSK Investigational Site
Memphis, Tennessee, United States, 38120 收起 <<
United States, Pennsylvania
... 展开 >>
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
United States, Texas
Texas Children's Hospital
Houston, Texas, United States, 77030 收起 <<
Pancreatic Adenocarcinoma
... 展开 >> Pancreatic Cancer 收起 <<
Phase 1
Completed
-
United States, California
... 展开 >>
City of Hope Medical Center
Duarte, California, United States, 91010
Scripps Green Hospital/Scripps Cancer Center
La Jolla, California, United States, 92037
United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210 收起 <<
United States, Alabama
... 展开 >>
GSK Investigational Site
Birmingham, Alabama, United States, 35233
United States, Arkansas
GSK Investigational Site
Little Rock, Arkansas, United States, 72202
United States, California
GSK Investigational Site
San Diego, California, United States, 92123
United States, Florida
GSK Investigational Site
Jacksonville, Florida, United States, 32209
United States, Kentucky
GSK Investigational Site
Lexington, Kentucky, United States, 40503
GSK Investigational Site
Louisville, Kentucky, United States, 40202
United States, Louisiana
GSK Investigational Site
New Orleans, Louisiana, United States, 70112
United States, North Carolina
GSK Investigational Site
Durham, North Carolina, United States, 27705
United States, Ohio
GSK Investigational Site
Cincinnati, Ohio, United States, 45229
United States, Texas
GSK Investigational Site
Galveston, Texas, United States, 77555-0653
Chile
GSK Investigational Site
Santiago, Región Metro De Santiago, Chile, 7580206
South Africa
GSK Investigational Site
Brits, South Africa, 2000
GSK Investigational Site
George, South Africa, 6529 收起 <<
United States, California
... 展开 >>
GSK Investigational Site
Carmichael, California, United States, 95608
GSK Investigational Site
Davis, California, United States, 95616
GSK Investigational Site
Riverside, California, United States, 92506
GSK Investigational Site
Sacramento, California, United States, 92585
United States, Indiana
GSK Investigational Site
Fort Wayne, Indiana, United States, 46804
GSK Investigational Site
Indianapolis, Indiana, United States, 46202
United States, Massachusetts
GSK Investigational Site
Boston, Massachusetts, United States, 02115
United States, New York
GSK Investigational Site
New York, New York, United States, 10011
GSK Investigational Site
New York, New York, United States, 10029
GSK Investigational Site
Stony Brook, New York, United States, 11794
GSK Investigational Site
The Bronx, New York, United States, 10461
United States, North Carolina
GSK Investigational Site
Chapel Hill, North Carolina, United States, 27599
United States, Oklahoma
GSK Investigational Site
Tulsa, Oklahoma, United States, 74104
United States, Oregon
GSK Investigational Site
Portland, Oregon, United States, 97210
United States, Texas
GSK Investigational Site
Houston, Texas, United States, 77030
United States, Utah
GSK Investigational Site
Salt Lake City, Utah, United States, 84132
United States, Washington
GSK Investigational Site
Seattle, Washington, United States, 98104 收起 <<
United States, Louisiana
... 展开 >>
LSU Eye Center
Recruiting
New Orleans, Louisiana, United States, 70112
Children's Hospital
Recruiting
New Orleans, Louisiana, United States, 70118
Principal Investigator: Herbert E Kaufman, MD 收起 <<
United States, New York
... 展开 >>
New York State Psychiatric Institute
Recruiting
New York, New York, United States, 10032
Contact: Julianna Pollina, BS 646-774-8638 julianna.pollina@nyspi.columbia.edu
Contact: Mariasofia Katsikoumbas, BS 646-774-8641 mariasofia.katsikoumbas@nyspi.columbia.edu
Principal Investigator: Davangere Devanand, MD
Sub-Investigator: Edward Huey, MD
Sub-Investigator: Yaakov Stern, PhD 收起 <<
United States, Texas
... 展开 >>
Houston Methodist
Recruiting
Houston, Texas, United States, 77030
Contact: Brent Bell, PA-C 713-394-1105 bcbell@tmhs.org
Contact: Edward B Butler, MD ebutler@tmhs.org
Principal Investigator: Edward B Butler, MD 收起 <<
United States, California
... 展开 >>
C.I. Trials, Inc.-Los Angeles County
Bellflower, California, United States, 90706
University of California, Los Angeles
Los Angeles, California, United States, 90095
University of California, Riverside at C.I. Trials, Inc.-Inland Empire
Riverside, California, United States, 92506
C.I. Trials, Inc.-Orange County
Santa Ana, California, United States, 92705
United States, Connecticut
Yale University
New Haven, Connecticut, United States, 06519
United States, Florida
Innovative Clinical Research, Inc.
Lauderhill, Florida, United States, 33319
United States, Indiana
Prevention and Recovery Center for Early Psychosis
Indianapolis, Indiana, United States, 46202
Indiana University Psychotic Disorders Clinic
Indianapolis, Indiana, United States, 46222
United States, Kansas
University of Kansas Medical Center-Witchita
Wichita, Kansas, United States, 67214
United States, Maryland
Maryland Psychiatric Research Center
Baltimore, Maryland, United States, 21228
Centers for Behavioral Health, LLC
Rockville, Maryland, United States, 20850
Sheppard Pratt Health System
Towson, Maryland, United States, 21204
United States, Oklahoma
Laureate Institute for Brain Research
Tulsa, Oklahoma, United States, 74136 收起 <<
HIV Infection
... 展开 >> Herpes Simplex Type II
HIV Infections 收起 <<
Phase 3
Completed
-
Argentina
... 展开 >> Fundación Huesped
Buenos Aires, Argentina, C1202ABB
Brazil
Instituto de Pesquisa Clínica Evandro Chagas
Rio de Janeiro, Brazil
Ambulatorio de Infectologia da UNIFESP
Sao Paulo, Brazil, 04040-002
Centro de Referencia e Treinamento em DST/AIDS
Sao Paulo, Brazil, 04121-000
Canada, Alberta
University of Alberta
Edmonton, Alberta, Canada, T6G 2C8
Canada, British Columbia
B.C. Women's Hospital & Health Centre - Oak Tree Clinic
Vancouver, British Columbia, Canada, V6H 1N1
Vancouver Infectious Disease Clinic
Vancouver, British Columbia, Canada, V6Z 2C7
Cool Aid Community Health Centre
VIctoria, British Columbia, Canada, V8W 1M8
Canada, Nova Scotia
CDHA, QEII Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
McMaster University Health Sciences Centre
Hamilton, Ontario, Canada, L8N 3Z5
The Ottawa Hospital, General Campus Divsions of Infectious Diseases
Ottawa, Ontario, Canada, K1H 8L6
University of Ottawa Health Services
Ottawa, Ontario, Canada, K1N 6N5
Sunnybrook Health Science Centre
Toronto, Ontario, Canada, M2N 3M5
St. Clair Medical Associates
Toronto, Ontario, Canada, M4K 1N1
Maple Leaf Medical Clinic
Toronto, Ontario, Canada, M5B 1L6
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
University Health Network
Toronto, Ontario, Canada, M5G 2N2
Windsor Regional Hospital
Windsor, Ontario, Canada, N8W 1E3
Canada, Quebec
Montreal Chest Institute
Montreal, Quebec, Canada, H2X 2P4
Centre Hospitalier de l'Université de Montréal
Montréal, Quebec, Canada, H2L 4M1
Canada
Centre Hospitalier Universitaire de Quebec-Pavillon CHUL
Quebec, Canada, G1V 4G2
United Kingdom
Brighton & Sussex University Hospitals NHS Trust
Brighton, United Kingdom, BN2 1ES
Guy's and St. Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
St. Stephen's AIDS Trust
London, United Kingdom, SW10 9NH
St. Mary's Hospital
London, United Kingdom, W2 1NY 收起 <<
Sweden
... 展开 >> Geriatric Centre, University Hospital in Umeå
Recruiting
Umeå, Västerbotten, Sweden, 90185
Contact: Hugo Lövheim, M.D., Ph.D. +46702979499 hugo.lovheim@umu.se 收起 <<
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