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/ Tryptanthrin/色氰菊酯

Tryptanthrin/色氰菊酯 {[allProObj[0].p_purity_real_show]}

货号：A273489 同义名： NSC 349447

Tryptanthrin是一种天然的生物碱化合物，具有基础的吲哚喹啉唑骨架。它具有广谱的生物活性，包括抗癌、抗炎、抗原虫、抗过敏、抗氧化和抗微生物等作用。

Tryptanthrin/色氰菊酯 化学结构 CAS号：13220-57-0
Tryptanthrin/色氰菊酯 化学结构
CAS号：13220-57-0
Tryptanthrin/色氰菊酯 3D分子结构
CAS号：13220-57-0
Tryptanthrin/色氰菊酯 化学结构 CAS号：13220-57-0
Tryptanthrin/色氰菊酯 3D分子结构 CAS号：13220-57-0
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Tryptanthrin/色氰菊酯 纯度/质量文件 产品仅供科研

货号：A273489 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >

Tryptanthrin/色氰菊酯 细胞实验

Cell Line
Concentration Treated Time Description References
Acinetobacter baumannii ATCC 17978 20 mg/mL 24 h Inhibited biofilm formation, inhibition rate 59% iScience. 2024 May 8;27(6):109942.
Acinetobacter baumannii AB102 20 mg/mL 24 h Inhibited biofilm formation, inhibition rate 85% iScience. 2024 May 8;27(6):109942.
Acinetobacter baumannii AB108 20 mg/mL 24 h Inhibited biofilm formation, inhibition rate 63% iScience. 2024 May 8;27(6):109942.
normal murine peritoneal macrophages ≤7.5 μM Tryptanthrin showed no significant cytotoxicity on normal murine peritoneal macrophages at concentrations inhibitory to leukemia cells. Cell Mol Immunol. 2009 Oct;6(5):335-42.
murine myelomonocytic leukemia WEHI-3B JCS cells 1-5 μM 48-72 h Tryptanthrin suppressed the proliferation of WEHI-3B JCS cells in a dose- and time-dependent manner, with an IC50 of 1.5 μM. Cell Mol Immunol. 2009 Oct;6(5):335-42.
HepG2 1.25, 2.5, 5, 10 μM 72 h Induces cellular senescence and inhibits proliferation of liver cancer cells Redox Biol. 2024 Oct;76:103323.
Huh7 1.25, 2.5, 5, 10 μM 72 h Induces cellular senescence and inhibits proliferation of liver cancer cells Redox Biol. 2024 Oct;76:103323.
B16F10 11 µM 72 h Evaluate the cytotoxicity of Tpn on B16F10 cells, results showed IC50 was 11 µM Cell Mol Life Sci. 2022 Aug 10;79(9):478.
SK-MEL-2 15 µM 72 h Evaluate the cytotoxicity of Tpn on SK-MEL-2 cells, results showed IC50 was 15 µM Cell Mol Life Sci. 2022 Aug 10;79(9):478.
SK-MEL-28 15 µM 72 h Evaluate the cytotoxicity of Tpn on SK-MEL-28 cells, results showed IC50 was 15 µM Cell Mol Life Sci. 2022 Aug 10;79(9):478.
A375 3 µM 72 h Evaluate the cytotoxicity of Tpn on A375 cells, results showed A375 cells were highly sensitive to Tpn Cell Mol Life Sci. 2022 Aug 10;79(9):478.
BV2 cells 10 μM 24 h Tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype. Neural Regen Res. 2025 Nov 1;20(11):3287-3301.
BV2 cells 2.5-50 μM 3, 6, 12, 24 h Evaluated the effects of tryptanthrin on BV2 cell viability and found that tryptanthrin was not cytotoxic at concentrations lower than 10.0 μM within 24 h. Neural Regen Res. 2025 Nov 1;20(11):3287-3301.
Human foreskin fibroblasts 18 μM 72 h To assess the toxicity of Tryptanthrin on normal cells, results showed only 22% cell death at 18 μM. Cell Prolif. 2020 Jan;53(1):e12710.
A431 cells 9 μM 72 h To assess the cytotoxicity of Tryptanthrin on A431 cells, results showed significant cytotoxicity at 9 μM. Cell Prolif. 2020 Jan;53(1):e12710.
mouse bone marrow-derived neutrophils 0.1 µM–10 µM 4 h TRYP dose-dependently reduced OSM release in GM-CSF-stimulated mouse bone marrow-derived neutrophils. Nutrients. 2024 Nov 28;16(23):4109.
neutrophils-like differentiated (d)HL-60 cells 0.1 µM–10 µM 1 h TRYP dose-dependently reduced OSM release and mRNA expression levels in GM-CSF-stimulated neutrophils-like dHL-60 cells. Nutrients. 2024 Nov 28;16(23):4109.

Tryptanthrin/色氰菊酯 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice WEHI-3B JCS cell-induced leukemia model Intraperitoneal injection 0.04, 0.08, 0.16 mg/kg 5 consecutive days Tryptanthrin significantly suppressed the growth of WEHI-3B JCS cells in BALB/c mice, with significant effects at doses of 0.08 and 0.16 mg/kg. Cell Mol Immunol. 2009 Oct;6(5):335-42.
BALB/c nude mice Liver cancer xenograft model Intraperitoneal injection 100 mg/kg Daily until the end of the experiment Inhibits tumor growth and induces tumor cell senescence Redox Biol. 2024 Oct;76:103323.
NOD-SCID mice Melanoma xenograft model Intradermal injection 12 mg/kg Daily for one month Evaluate the inhibitory effect of Tpn on melanoma growth in vivo, results showed Tpn significantly reduced tumor volume and metastasis Cell Mol Life Sci. 2022 Aug 10;79(9):478.
C57BL/6 male mice Spinal cord injury model Intragastric administration 30 mg/kg Once daily for 14 days Tryptanthrin promoted microglia polarization toward M2 phenotype by targeting the cGAS/STING/NF-κB axis, inhibited neuronal loss, and promoted tissue repair and functional recovery. Neural Regen Res. 2025 Nov 1;20(11):3287-3301.
Swiss albino mice DMBA/PMA-induced skin carcinogenesis model Topical application 0.5 mg or 1 mg 1 hour before each PMA application, for 16 weeks To evaluate the inhibitory effect of Tryptanthrin on skin cancer, results showed 60.1% reduction in tumor size and 59% reduction in tumor multiplicity at 1 mg dose. Cell Prolif. 2020 Jan;53(1):e12710.
Galleria mellonella Infection model Injection 50 mg/kg Single injection, observed for 96 hours Evaluated the effect of tryptanthrin on the virulence of A. baumannii, survival rate increased from 40% to 80% iScience. 2024 May 8;27(6):109942.
Male SD mice DSS-induced colitis model Intragastrical administration 39.2 mg/kg, 78.4 mg/kg, 156.8 mg/kg Twice a day for 8 days Tryptanthrin improves the health condition of mice with DSS-induced colitis by regulating the TNF-α/NF-κB and IL-6/STAT3 signaling pathways. Molecules. 2018 May 2;23(5):1062

Tryptanthrin/色氰菊酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.28mL

8.06mL

4.03mL

Tryptanthrin/色氰菊酯 技术信息

CAS号13220-57-0
分子式C15H8N2O2
分子量 248.24
SMILES Code O=C1C2=CC=CC=C2N2C1=NC1=CC=CC=C1C2=O
MDL No. MFCD00012073
别名 NSC 349447
运输蓝冰
InChI Key VQQVWGVXDIPORV-UHFFFAOYSA-N
Pubchem ID 73549
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 6 mg/mL(24.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Tryptanthrin | 13220-57-0 | Leukotriene Receptor | NO Synthase | LT Inhibitor | GPCR/G Protein | Immunology/Inflammation | NF-κB | Apoptosis | Leukotriene Receptor | NO Synthase | NF-κB | COX | TNF Receptor | Interleukin Related | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tryptanthrin/色氰菊酯 纯度/质量文件 | Tryptanthrin/色氰菊酯 实验方案 | Tryptanthrin/色氰菊酯 技术信息

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