There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Assess genotoxicity, significant increase in DNA tail percentage, concentration-dependent
J Xenobiot. 2023 Dec 21;14(1):15-30
Blood-brain barrier model cells
10 µM
30 minutes
Evaluation of triclocarban's ability to cross the blood-brain barrier, showing very good permeability
Int J Mol Sci. 2021 Dec 4;22(23):13121
Bifidobacterium infantis 272
100 nM
48 hours
To study the effect of Triclocarban on the growth of Bifidobacterium infantis 272. Results showed that 100 nM Triclocarban inhibited approximately 30% of bacterial growth.
Gut Microbes. 2020 Nov 9;12(1):1690364
Triclocarban/3,4,4′-三氯二苯脲 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Albino Swiss mice
Prenatal exposure model
Subcutaneous injection
5 mg/kg
Daily at 15–18 days of gestation
Prenatal exposure to triclocarban impaired ESR1 signaling, disrupted epigenetic status, and sex-specifically dysregulated the expression of neurogenesis- and neurotransmitter-related genes in the postnatal mouse brain
Int J Mol Sci. 2021 Dec 4;22(23):13121
C57BL/6 mice
DSS-induced colitis model
Dietary administration
80 ppm (~8 mg/kg/day)
3 weeks
To study the effect of Triclocarban on DSS-induced colitis. Results showed that Triclocarban exacerbated body weight loss, colon length reduction, increased plasma IL-6 levels, up-regulated IL-6 gene expression in the colon, increased leukocyte infiltration, and exaggerated crypt damage in the colon.
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