Tonabersat | SB-220453 | Gap Junction Modulator | AmBeed-信号通路专用抑制剂

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Tonabersat {[allProObj[0].p_purity_real_show]}

货号：A468702 同义名： SB-220453

Tonabersat is a gap-junction modulator.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Tonabersat 化学结构
CAS号：175013-84-0

Tonabersat 3D分子结构
CAS号：175013-84-0

规格	价格	会员价	库存	数量
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Tonabersat 纯度/质量文件产品仅供科研

货号：A468702 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

Tonabersat 生物活性

描述	Tonabersat is a gap-junction modulator.

Tonabersat 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00332007	Migraine With Aura	Phase 2	Completed	-	Denmark ... 展开 >> Danish Headache Centre, Department of Neurology, Glostrup Hospital Copenhagen, Denmark 收起 <<
NCT00534560	Migraine Without Aura ... 展开 >> Migraine With Aura 收起 <<	Phase 2	Completed	-	-
NCT00311662	Migraine Without Aura ... 展开 >> Migraine With Aura 收起 <<	Phase 2	Completed	-	Denmark ... 展开 >> Glostrup Amtssygehus, Neurologisk Ambulatorium N01 Copenhagen, Denmark, Glostrup 2600 Bispebjerg Hospital, Neurolgisk Afdeling N Copenhagen, Denmark, Kobenhavn NV 2400 Hungary Kenézy Gyula County Hospital, Dept of Neurology Debrecen, Hungary, Debrecen 1145 Petz Aladár Megyei Oktató Kórház Gyor, Hungary, Gyor 9024 Borsod Abauj Zemplén Megyei Kórház, Neurologiai Osztaly Miskolc, Hungary, Miskolc 3526 Zala County Hospital, Department of Cardiology Zalaegerszeg, Hungary, Zalaegerszeg 8900 South Africa Quinta-Med Bloemfontein, South Africa, Bloemfontein 9301 Chris Barnard Memorial Hospital Cape Town, South Africa, West Cape 8001 St. Augustine's Medical Mews Durban, South Africa, KZ-Natal 4001 Francois Le Clus Johannesburg, South Africa, Gauteng 1619 Dr I Engelbrecht Lyttleton, South Africa, Guateng 0157 Pretoria East Hospital, Neuro-Orthopaedic Unit Pretoria, South Africa, Gauteng 0044 Intercare Corporate Office Pretoria, South Africa, Gauteng 0081 Dr J Bouwer Pretoria, South Africa, Gauteng 0082 Little Company of Mary, Neurospinal Building Pretoria, South Africa, Gauteng 0181 SCION Clinical Research, 316 Medi-Clinic Heart Hospital Pretoria, South Africa, Guateng 0002 United Kingdom The National Hospital for Neurology & Neurosurgery London, United Kingdom, WC1N 3BG 收起 <<

Tonabersat 参考文献

[1]Chen Q, Boire A, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 26;533(7604):493-498.

[2]Silberstein SD, Schoenen J, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.

Tonabersat 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.26mL

12.76mL

2.55mL

1.28mL

25.52mL

5.10mL

2.55mL

Tonabersat 技术信息

CAS号	175013-84-0
分子式	C₂₀H₁₉ClFNO₄
分子量	391.82
SMILES Code	O=C(N[C@@H]1[C@H](O)C(C)(C)OC2=C1C=C(C(C)=O)C=C2)C3=CC=C(F)C(Cl)=C3
MDL No.	MFCD00944458

别名	SB-220453
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form

溶解方案

细胞实验：

DMSO: 105 mg/mL(267.98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

方案四

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00332007	Migraine With Aura	Phase 2	Completed	-	Denmark ... 展开 >> Danish Headache Centre, Department of Neurology, Glostrup Hospital Copenhagen, Denmark 收起 <<
NCT00534560	Migraine Without Aura ... 展开 >> Migraine With Aura 收起 <<	Phase 2	Completed	-	-
NCT00311662	Migraine Without Aura ... 展开 >> Migraine With Aura 收起 <<	Phase 2	Completed	-	Denmark ... 展开 >> Glostrup Amtssygehus, Neurologisk Ambulatorium N01 Copenhagen, Denmark, Glostrup 2600 Bispebjerg Hospital, Neurolgisk Afdeling N Copenhagen, Denmark, Kobenhavn NV 2400 Hungary Kenézy Gyula County Hospital, Dept of Neurology Debrecen, Hungary, Debrecen 1145 Petz Aladár Megyei Oktató Kórház Gyor, Hungary, Gyor 9024 Borsod Abauj Zemplén Megyei Kórház, Neurologiai Osztaly Miskolc, Hungary, Miskolc 3526 Zala County Hospital, Department of Cardiology Zalaegerszeg, Hungary, Zalaegerszeg 8900 South Africa Quinta-Med Bloemfontein, South Africa, Bloemfontein 9301 Chris Barnard Memorial Hospital Cape Town, South Africa, West Cape 8001 St. Augustine's Medical Mews Durban, South Africa, KZ-Natal 4001 Francois Le Clus Johannesburg, South Africa, Gauteng 1619 Dr I Engelbrecht Lyttleton, South Africa, Guateng 0157 Pretoria East Hospital, Neuro-Orthopaedic Unit Pretoria, South Africa, Gauteng 0044 Intercare Corporate Office Pretoria, South Africa, Gauteng 0081 Dr J Bouwer Pretoria, South Africa, Gauteng 0082 Little Company of Mary, Neurospinal Building Pretoria, South Africa, Gauteng 0181 SCION Clinical Research, 316 Medi-Clinic Heart Hospital Pretoria, South Africa, Guateng 0002 United Kingdom The National Hospital for Neurology & Neurosurgery London, United Kingdom, WC1N 3BG 收起 <<

Tonabersat {[allProObj[0].p_purity_real_show]}

Tonabersat 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Tonabersat 质控信息

Tonabersat 生物活性

Tonabersat 临床研究

Tonabersat 参考文献

Tonabersat 实验方案

Tonabersat 技术信息

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Tonabersat {[allProObj[0].p_purity_real_show]}

Tonabersat 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Tonabersat 质控信息

Tonabersat 生物活性

Tonabersat 临床研究

Tonabersat 参考文献

Tonabersat 实验方案

Tonabersat 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Tonabersat 纯度/质量文件产品仅供科研