Toltrazuril is frequently administered for the metaphylactic control of piglet cystoisosporosis. Toltrazuril has a high efficacy for in the control of parasitological and clinical outcomes of experimental C. suis infection[3]. Already one application of toltrazuril was significantly able to delay the outbreak of neosporosis in newborn mice, when compared to placebo-treated infected controls. However, the number of diseased and Neospora-positive pups (46% and 47%, respectively) was markedly reduced after three-time-toltrazuril treatment compared to all other groups[4]. In piglets, treatment with the recommended (20 mg/kg) dose of toltrazuril completely suppressed oocyst shedding and diarrhea in group Wien-20[5]. Cystoisospora suis causes diarrhoeal disease and reduced weight gain in suckling piglets, and a toltrazuril-based oral suspension is available for treatment. Treatment with both the injectable (Forceris®) and the oral (Baycox®) formulation of toltrazuril in the prepatent period were safe and highly effective against experimental infection with C. suis in newborn piglets[6].
搜索
