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Tolnaftate/托萘酯 {[allProObj[0].p_purity_real_show]}

货号:A357832 同义名: NP-27; NSC 233648

Tolnaftate是一种合成的硫代氨基甲酸酯类抗真菌药。

Tolnaftate/托萘酯 化学结构 CAS号:2398-96-1
Tolnaftate/托萘酯 化学结构
CAS号:2398-96-1
Tolnaftate/托萘酯 3D分子结构
CAS号:2398-96-1
Tolnaftate/托萘酯 化学结构 CAS号:2398-96-1
Tolnaftate/托萘酯 3D分子结构 CAS号:2398-96-1
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Tolnaftate/托萘酯 纯度/质量文件 产品仅供科研

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Tolnaftate/托萘酯 生物活性

描述 Tolnaftate, is a topical antifungal agent described to be effective in the treatment of otomycosis[3]. Cells grown in the presence of tolnaftate (at the IC50) showed a reduced content of total phospholipids and sterols whereas there was an increase in total RNA content. The activity of membrane-bound enzymes did not change on treatment with tolnaftate (10 x MIC) whereas an increase in the leakage of intracellular 32P was observed. Activity of phosphodiesterase decreased and 5'-nucleotidase increased in tolnaftate-resistant cells[4]. In vitro skin penetration studies revealed that after application of 1% (w/w) tolnaftate solution in polyethylene glycol 400 for 24 hours, the mean amount of tolnaftate penetrating into the epidermis and dermis was 2.60 +/- 0.28 mg/cm2 and 0.92 +/- 0.12 mg/cm2, respectively[5]. The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. The biochemical action of tolnaftate and tolciclate is thus similar to that of the allylamine antimycotics naftifine and terbinafine[6].

Tolnaftate/托萘酯 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02413840 COPD Anxiety ... 展开 >> Depression 收起 << Not Applicable Unknown - China ... 展开 >> Beijing institute of respiratory diseases Recruiting Beijing, China Contact: Ting Yang    8613651380809 收起 <<
NCT02187679 Tourette Syndrome ... 展开 >> Chronic Vocal Tic 收起 << Not Applicable Unknown - United States, Michigan ... 展开 >> Detroit Clinical Research Center Recruiting Farmington Hills, Michigan, United States, 48334 Contact: Candice Shallal, BS    248-716-7009 ext 190    candice.shallal@dcrc.us    Principal Investigator: Edward Dabrowski, MD 收起 <<
NCT00401908 - Withdrawn - United States, New York ... 展开 >> Maimonides Medical Center Brooklyn, New York, United States, 11219 收起 <<

Tolnaftate/托萘酯 参考文献

[1]Georgopapadakou NH, Bertasso A. Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.

[2]Ryder NS, Frank I, et al. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60.

[3]Jimenez-Garcia L, Celis-Aguilar E, Díaz-Pavón G, et al. Efficacy of topical clotrimazole vs. topical tolnaftate in the treatment of otomycosis. A randomized controlled clinical trial [published online ahead of print, 2019 Feb 18]. Braz J Otorhinolaryngol. 2019;S1808-8694(18)30274-X

[4]Gupta MP, Kapur N, Bala I, Khuller GK. Studies on the mode of action of tolnaftate in Microsporum gypseum. J Med Vet Mycol. 1991;29(1):45‐52

[5]Kezutyte T, Kornysova O, Maruska A, Briedis V. Assay of tolnaftate in human skin samples after in vitro penetration studies using high performance liquid chromatography. Acta Pol Pharm. 2010;67(4):327‐334

[6]Ryder NS, Frank I, Dupont MC. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986;29(5):858‐860

Tolnaftate/托萘酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.26mL

3.25mL

1.63mL

32.53mL

6.51mL

3.25mL

Tolnaftate/托萘酯 技术信息

CAS号2398-96-1
分子式C19H17NOS
分子量 307.41
SMILES Code S=C(OC1=CC=C2C=CC=CC2=C1)N(C)C3=CC=CC(C)=C3
MDL No. MFCD00056611
别名 NP-27; NSC 233648; Tolnaftate, Tinactin, Tinaderm, Aftate, NP-27, NP 27, NP27; SCH 10144
运输蓝冰
InChI Key FUSNMLFNXJSCDI-UHFFFAOYSA-N
Pubchem ID 5510
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

溶解方案

DMSO: 50 mg/mL(162.65 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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