Tiratricol/替拉曲可
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货号：A244345
同义名：
3,3',5-Triiodothyroacetic acid; 3,3′,5-Triiodothyroacetic acid
Tiratricol 是一种甲状腺激素类似物，具有肝脏作用，已用于抑制垂体 TSH 分泌，并减轻外垂体的类甲状腺激素效应。Tiratricol 还是一种细胞内毒素中和剂，可以抑制 LPS 和 lipid A 的细胞毒性，IC50s 分别为 20 μM 和 32μM。
Tiratricol/替拉曲可 化学结构
Tiratricol/替拉曲可 3D分子结构
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Tiratricol/替拉曲可 纯度/质量文件 产品仅供科研
货号：A244345
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Science , 2025, 387(6729): eadp5637. Ambeed. • Nat. Electron. , 2025, 8, 66-74. Ambeed. • Adv. Mater. , 2025, 2416621. Ambeed. • Adv. Mater. , 2025, 2410493. Ambeed. • Adv. Mater. , 2025, 2420319. Ambeed. A106129
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Tiratricol/替拉曲可 质控信息
Tiratricol/替拉曲可 生物活性
描述
Thyroid hormone receptor is a type of nuclear receptor which control transcription and have effects in all cells within the body. Tiratricol is an agonist of the thyroid hormone receptor TRα and TRβ (EC50= 1.81 and 4.13nM, respectively)[3] [4] [5] [6]
Tiratricol/替拉曲可 参考文献
[1] Carvalho GA, Ramos HE. [Thyroid hormone resistance syndrome] . Arq Bras Endocrinol Metabol. 2004 Feb;48(1):83-92. Epub 2004 Jun 1.
[2] Brenta G, Schnitman M, et al. Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. J Clin Endocrinol Metab. 2003 Nov;88(11):5287-92.
[3] Oka T, Mitsui-Watanabe N, Tatarazako N, et al. Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors. J Appl Toxicol. 2013;33(9):991-1000.
[4] Kersseboom S, Horn S, Visser WE, et al. In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. Mol Endocrinol. 2014;28(12):1961-1970.
[5] Alvarez L, Burgueño A, Zeni S, et al. Comparison of the effects of 3,5,3'-triiodothyroacetic Acid and triiodothyronine on goiter prevention and involution and on hepatic and skeletal parameters in rats. Horm Metab Res. 2004;36(5):291-297.
[6] Ha HC, Jang JM, Zhou D, et al. 3, 5, 3'-Triiodothyroacetic acid (TRIAC) is an anti-inflammatory drug that targets toll-like receptor 2. Arch Pharm Res. 2018;41(10):995-1008.
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Tiratricol/替拉曲可 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.61mL
0.32mL
0.16mL
8.04mL
1.61mL
0.80mL
16.08mL
3.22mL
1.61mL
Tiratricol/替拉曲可 技术信息
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