Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. Tetramisole, a well documented TNAP (tissue non-specific alkaline phosphatase) inhibitor, to block TNAP activity. Tetramisole reduced neuronal response amplitude in a dose-dependent manner. Tetramisole also decreased axonal conduction velocity. The decrease of axonal conduction velocity and preliminary intracellular data suggest that tetramisole blocks voltage-dependent sodium channels[3]. Nervous involvement in the acute toxicity of tetramisole. Subcutaneous injection of tetramisole at 0.5 and 1mg/kg did not significantly affect general locomotor activity of the mice in 5-min open-field activity test or negative geotaxis performance and landing foot splay. However, the 1 mg/kg dose of tetramisole significantly increased the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Repeated tetramisole treatments (0.5 and 1 mg/kg) also significantly decreased the time needed to complete the negative geotaxis task and reduced landing foot splay[4].
搜索
