There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
β-Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule that in metazoans exerts a crucial role in a multitude of developmental and homeostatic processes. More specifically, β-catenin is an integral structural component of cadherin-based adherens junctions, and the key nuclear effector of canonical Wnt signalling in the nucleus[3]. BC2059 is a potent inhibitor of β-Catenin. BC2059 attenuates β-catenin levels, in both the cytoplasm and the nucleus, reducing the transcriptional activity of the TCF4/LEF complex and the expression of its target gene axin 2. Treatment of HMCL (human myeloma cell lines) with BC2059 inhibits proliferation and induces apoptosis in a dose-dependent manner. This is also observed in HMCL-stromal cell cocultures, mitigating the protective effect afforded by the stroma. Similarly, BC2059 induces apoptosis in primary multiple myeloma samples in vitro, causing minimal apoptosis on healthy peripheral blood mononuclear cells[4]. BC2059 treatment disrupted the binding of β-catenin with the scaffold protein transducin β-like 1 and proteasomal degradation and decline in the nuclear levels of β-catenin. BC2059 treatment dose-dependently induced apoptosis of cultured and primary AML BPCs (acute myeloid leukemia blast progenitor cells). Treatment with BC2059 also significantly improved the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs, exhibiting nuclear expression of β-catenin[5]. In xenograft models of human myelomatosis, BC2059 delayed tumor growth and prolonged survival with minor on-target side effects. These findings support further clinical evaluation of BC2059 for the treatment of multiple myeloma[4].
Tegatrabetan 细胞实验
Cell Line
Concentration
Treated Time
Description
References
hFOB1.19
> 1 µM
72 h
hFOB1.19 cells were not sensitive to Tegavivint
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
MV4-11 cells
20-100 nM
48 h
BC2059 induced apoptosis in FLT3-ITD expressing MV4-11 cells
Leukemia. 2015 Jun;29(6):1267-78.
DLBCL cell lines
2-100 nM
24 h
induced DLBCL cell death
Haematologica. 2021 Nov 1;106(11):2927-2939.
TCCC-OS84
21.6 nM
72 h
TCCC-OS84 cells were sensitive to Tegavivint, and it inhibited the expression of b-catenin and c-Myc
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
TCCC-OS63
36.6 nM
72 h
TCCC-OS63 cells were sensitive to Tegavivint, and it inhibited the expression of b-catenin and c-Myc
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
LM7
18.0 nM
72 h
LM7 cells were sensitive to Tegavivint, and it inhibited the expression of b-catenin and c-Myc
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
SaOS-2
6.2 nM
72 h
SaOS-2 cells were sensitive to Tegavivint, and it inhibited the expression of b-catenin and c-Myc
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
BCPAP cells
100 nM
24 h
Tegavivint significantly reversed the impact of CDH4 on tube formation in HUVECs.
J Transl Med. 2024 Feb 24;22(1):201.
TPC-1 cells
100 nM
24 h
Tegavivint effectively counteracted the pro-migratory and invasive effects of CDH4 on PTC cells.
J Transl Med. 2024 Feb 24;22(1):201.
CD34+ AML blast progenitor cells
20-100 nM
48 h
BC2059 dose-dependently induced apoptosis in CD34+ AML blast progenitor cells
Leukemia. 2015 Jun;29(6):1267-78.
OCI-AML3 cells
20-100 nM
120 h
BC2059 dose-dependently inhibited cell proliferation and induced apoptosis
Leukemia. 2015 Jun;29(6):1267-78.
Tegatrabetan 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Osteosarcoma PDX model
Intraperitoneal injection
50 mg/kg
Twice weekly for 4 weeks
Tegavivint significantly suppressed PDX tumor growth and reduced lung metastasis
J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.
Nude mice
Lung metastatic model and tumorigenicity studies
Intraperitoneal injections
20 mg/kg
Twice weekly for three consecutive weeks per cycle, repeated over two cycles lasting 28 days each
Tegavivint significantly impeded tumor formation in CDH4-overexpressing TPC-1 cells and significantly reduced the volume and weight of tumors compared to both control and CDH4-overexpressing groups.
J Transl Med. 2024 Feb 24;22(1):201.
NOD/SCID mice
AML xenograft model
Tail vein injection
1.0, 5.0, 10.0 mg/kg
Twice weekly for 3 weeks
BC2059 significantly improved the survival of NOD/SCID mice
搜索
HazMat Fee +
