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首页 / 抑制剂/激动剂 / 抗感染 / Antiparasitic / Tafenoquine/他非诺喹

Tafenoquine/他非诺喹 {[allProObj[0].p_purity_real_show]}

货号：A299706 同义名： WR 238605

Tafenoquine是一种口服活性抗疟药，正在被研究作为治疗和预防疟疾的潜在药物。

Tafenoquine/他非诺喹 化学结构 CAS号：106635-80-7
Tafenoquine/他非诺喹 化学结构
CAS号：106635-80-7
Tafenoquine/他非诺喹 3D分子结构
CAS号：106635-80-7
Tafenoquine/他非诺喹 化学结构 CAS号：106635-80-7
Tafenoquine/他非诺喹 3D分子结构 CAS号：106635-80-7
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Tafenoquine/他非诺喹 纯度/质量文件 产品仅供科研

货号：A299706 标准纯度： {[allProObj[0].p_purity_real_show]}
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Tafenoquine/他非诺喹 生物活性

描述 The 8-aminoquinoline (8AQ) class of anti-malarial compounds is extremely important in the fight against malaria, as this class of molecules is unique due to the efficacy against relapsing forms of malaria. Tafenoquine (TQ) is an 8-aminoquinoline (8AQ) that is currently in late stage development as an anti-malarial prophylactic agent. In the CYP 2D knock-out mouse model, there was no luminescence signal at either 48 or 72 hr post-infection indicating that TQ at its ED100 (3 mg/kg) prevented P. berghei infection. TQ was tested at two times its ED100 in the humanized/CYP 2D6 knock-in mouse strain. The results showed that there was less luminescence signal in all five mice at 48 hr (as compared to WT-infected controls) and no detectable luminescence signal at 72 hr post-inoculation. Five out of five WT mice treated with TQ had no detectable parasite burden after 31 days, in comparison to the WT infection control or the CYP 2D knock-out mice treated with TQ. Those results illustrated that TQ is active in the presence of the CYP 2D gene cluster[3].

Tafenoquine/他非诺喹 参考文献

[1]Dow G, Smith B. The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg). Malar J. 2017 May 19;16(1):209.

[2]Chu CS, Bancone G, et al. Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens. PLoS Med. 2017 Feb 7;14(2):e1002224.

[3]Marcsisin SR, Sousa JC, Reichard GA, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014;13:2.

Tafenoquine/他非诺喹 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.79mL

2.16mL

1.08mL

21.58mL

4.32mL

2.16mL

Tafenoquine/他非诺喹 技术信息

CAS号106635-80-7
分子式C24H28F3N3O3
分子量 463.49
SMILES Code CC(NC1=C2N=C(OC)C=C(C)C2=C(OC3=CC=CC(C(F)(F)F)=C3)C(OC)=C1)CCCN
MDL No. MFCD00598712
别名 WR 238605
运输蓝冰
InChI Key LBHLFPGPEGDCJG-UHFFFAOYSA-N
Pubchem ID 115358
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

Tags: Tafenoquine | 106635-80-7 | WR 238605 | WR238605 | WR-238605 | Parasite Inhibitor | Anti-infection | Parasite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tafenoquine/他非诺喹 纯度/质量文件 | Tafenoquine/他非诺喹 生物活性 | Tafenoquine/他非诺喹 参考文献 | Tafenoquine/他非诺喹 实验方案 | Tafenoquine/他非诺喹 技术信息

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