There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Tacalcitol promotes normal bone development by regulating calcium.
Tacalcitol monohydrate 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDA-MB-231 cells
100 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on MDA-MB-231 cells, results showed that Tacalcitol combined with anastrozole significantly inhibited cell proliferation.
Int J Mol Sci. 2021 Mar 9;22(5):2781
SKBR-3 cells
100 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on SKBR-3 cells, results showed that Tacalcitol combined with anastrozole significantly inhibited cell proliferation.
Int J Mol Sci. 2021 Mar 9;22(5):2781
T47D cells
10 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on T47D cells, results showed that Tacalcitol combined with anastrozole significantly inhibited cell proliferation.
Int J Mol Sci. 2021 Mar 9;22(5):2781
MCF-7 cells
100 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on MCF-7 cells, results showed that Tacalcitol combined with anastrozole significantly inhibited cell proliferation.
Int J Mol Sci. 2021 Mar 9;22(5):2781
HL-60 cells
8 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on HL-60 cells, results showed significant antiproliferative activity.
Cancers (Basel). 2022 Jan 13;14(2):387
Thp-1 cells
6 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on Thp-1 cells, results showed significant antiproliferative activity.
Cancers (Basel). 2022 Jan 13;14(2):387
MV-4-11 cells
3 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol on MV-4-11 cells, results showed significant antiproliferative activity.
Cancers (Basel). 2022 Jan 13;14(2):387
MC38/0 cells
100 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol (PRI-2191) in combination with 5-FU on MC38/0 cells. Results showed that PRI-2191 significantly enhanced the antiproliferative effect of 5-FU on MC38/0 cells.
BMC Cancer. 2013 Jun 18;13:294
HT-29 cells
100 nM
120 hours
To evaluate the antiproliferative effect of Tacalcitol (PRI-2191) in combination with 5-FU on HT-29 cells. Results showed that PRI-2191 significantly enhanced the antiproliferative effect of 5-FU on HT-29 cells.
BMC Cancer. 2013 Jun 18;13:294
MV-4-11
10 nM
48-120 hours
Increased proportion of cells in G1/G0 phase, decreased proportion in S phase
Int J Mol Sci. 2022 Apr 30;23(9):5019
67NR cells
100 nM
72 hours
To evaluate the effect of Tacalcitol and its analogs on the proliferation of 67NR cells. The results showed that Tacalcitol and its analogs significantly inhibited the proliferation of 67NR cells.
Int J Oncol. 2018 Jan;52(1):103-126
4T1 cells
100 nM
72 hours
To evaluate the effect of Tacalcitol and its analogs on the proliferation of 4T1 cells. The results showed that Tacalcitol and its analogs did not significantly affect the proliferation of 4T1 cells.
Int J Oncol. 2018 Jan;52(1):103-126
HL-60
10 nM
72 hours
Increased proportion of cells in G1/G0 phase, decreased proportion in S phase
Int J Mol Sci. 2022 Apr 30;23(9):5019
MCF-7 cells
1000, 100, 10, 1 nM
72 hours
To evaluate the antiproliferative activity of Tacalcitol (PRI-2191) against MCF-7 breast cancer cells. Results showed that Tacalcitol significantly inhibited cell proliferation at 100 nM concentration.
Cancers (Basel). 2013 Oct 31;5(4):1355-78
Thp-1
10 nM
96 hours
Increased proportion of cells in G1/G0 phase, decreased proportion in S phase
Int J Mol Sci. 2022 Apr 30;23(9):5019
Tacalcitol monohydrate 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 female mice
MC38 mouse colon cancer model
Subcutaneous injection
1 μg/kg/day
Three times a week, until the end of the experiment
To evaluate the antitumor effect of Tacalcitol (PRI-2191) in combination with 5-FU on the MC38 mouse colon cancer model. Results showed that the combined treatment significantly inhibited tumor growth and prolonged the survival time of mice.
BMC Cancer. 2013 Jun 18;13:294
BALB/c mice
4T1 mammary tumor model
Subcutaneous injection
1.0 µg/kg
Three times a week, starting from day 7 after tumor inoculation
To assess the effect of Tacalcitol on Th17 cells in the 4T1 tumor model in young and aged OVX mice. Results showed that Tacalcitol increased Th17 cell gene expression and IL-17A secretion in young mice but decreased these effects in aged OVX mice.
Aging Dis. 2020 Mar 9;11(2):241-253
SCID mice
MCF-7 breast cancer model
Subcutaneous injection
1.0 μg/kg
Three times a week for 46 days
To evaluate the antitumor effect of Tacalcitol in vivo on MCF-7 tumor growth, results showed that Tacalcitol significantly inhibited tumor growth.
Int J Mol Sci. 2021 Mar 9;22(5):2781
NU/J mice
Subcutaneous human breast MCF-7 tumor model
Subcutaneous injection
1.0 μg/kg/day
Three times a week, up to day 67 of the experiment
To evaluate the antitumor activity of Tacalcitol (PRI-2191) in the MCF-7 breast cancer model. Results showed that PRI-2191 significantly inhibited tumor growth on days 60 and 62 of the experiment.
Cancers (Basel). 2013 Oct 31;5(4):1355-78
BALB/c female mice
4T1 mouse mammary gland cancer model
Subcutaneous injection
PRI-2191, 1.0 µg/kg
Thrice a week, starting from day 7 after tumor inoculation
To evaluate the effect of Tacalcitol analog PRI-2191 on tumor growth and metastasis in the 4T1 mouse mammary gland cancer model. The results showed that PRI-2191 did not influence the growth of primary tumors but significantly increased lung metastasis.
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