Tabersonine, a natural product isolated and purified from the root bark of Voacanga africana Stapf, is a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD.
Tabersonine/水甘草碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
THP-1 cells
10 μM
3 h
To inhibit NLRP3 inflammasome activation. Results showed that Tab inhibited IL-1β production in THP-1 cells.
Acta Pharmacol Sin. 2023 Jun;44(6):1252-1261.
Bone marrow-derived macrophages (BMDMs)
1 μM, 5 μM, 10 μM
30 min
Tab inhibited NLRP3-mediated IL-1β production and suppressed the assembly of NLRP3 inflammasome, especially the interaction between NLRP3 and ASC.
Acta Pharmacol Sin. 2023 Jun;44(6):1252-1261.
HS633T cells
10 µM
24 h
To investigate the antiviral and immunomodulatory effects of Tabersonine on ONNV infection. Results showed that Tabersonine significantly downregulated E1 and E2 gene expression and reduced viral progeny production.
Pharmaceuticals (Basel). 2023 Aug 9;16(8):1125.
rat calvarial osteoblasts
5 or 10 µM
24 h
To evaluate the effect of Tabersonine on the viability of dexamethasone-treated osteoblasts, results showed Tabersonine restored cell viability
AMB Express. 2020 Sep 11;10(1):165.
Tabersonine/水甘草碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
Peritonitis, acute lung injury, and sepsis models
Gavage or intraperitoneal injection
10, 20, or 40 mg/kg
Single administration
Tab significantly ameliorated NLRP3-driven diseases, such as peritonitis, acute lung injury, and sepsis.
Acta Pharmacol Sin. 2023 Jun;44(6):1252-1261.
Female Sprague-Dawley rats
Dexamethasone-induced osteoporosis model
Intraperitoneal injection
20 or 40 mg/kg
Once daily for 60 days
To evaluate the effect of Tabersonine on bone histopathology and bone mineral density, results showed Tabersonine improved osteoporosis
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