Sulfathiazole/磺胺噻唑 {[allProObj[0].p_purity_real_show]}

Sulfathiazole/磺胺噻唑 质控信息

Sulfathiazole/磺胺噻唑 生物活性

描述

Sulfathiazole, an organosulfur compound, is used as a short-acting sulfonamide antibiotic.Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level[3]. Sulfathiazole sorption to inorganic sorbents exhibited pronounced pH dependence consistent with sorbate speciation and sorbent charge properties.Sulfathiazole cations were most important for sorption to clay minerals [4]. The sorption of STZ (Sulfathiazole) on GMC-treated(giant Miscanthus) soils is greatly enhanced, mainly through the greater micropore surfaces, the abundance of hydrophilic functional groups over time, and π+-π electron donor-acceptor interaction at low pH[5].

Sulfathiazole/磺胺噻唑 细胞实验

Cell Line PC3 MCF-7 HaCaT	Concentration	Treated Time	Description	References
PC3	200 µM	24 and 48 hours	Evaluation of anticancer activity, Ru(III)-STZ complex showed higher activity than free ligand	Int J Mol Sci. 2021 Dec 15;22(24):13482
MCF-7	200 µM	24 and 48 hours	Evaluation of anticancer activity, Ru(III)-STZ complex showed higher activity than free ligand	Int J Mol Sci. 2021 Dec 15;22(24):13482
HaCaT	200 µM	24 and 48 hours	Evaluation of cytotoxicity, results showed Ru(III)-STZ complex significantly reduced cell viability	Int J Mol Sci. 2021 Dec 15;22(24):13482
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Sulfathiazole/磺胺噻唑 动物实验

Species Pseudomonas rhodesiae and Raoultella terrigena Wistar rats White mice	Animal Model Duo-species biofilm model Oral administration model Plague infection model	Administration	Dosage	Frequency	Description	References
Pseudomonas rhodesiae and Raoultella terrigena	Duo-species biofilm model	Biofilm culture	100 µM	80 days	To study the effect of sulfathiazole on the development of bacterial resistance in duo-species biofilms. Results showed that Pseudomonas rhodesiae rapidly evolved resistance to sulfathiazole in duo-species conditions, whereas it could not evolve resistance in monospecies conditions.	Appl Environ Microbiol. 2023 Oct 31;89(10):e0115523
Wistar rats	Oral administration model	Oral	50 mg	Single dose, duration of 6 hours	To study the influence of the tenside (monolaurin of sucrose) on the rate of absorption of sulfathiazole. It was found that 0.001% solution of tenside can increase the rate of absorption by cca 50% and a two-fold increase in absolute bioavailability can be reached.	Molecules. 2021 Sep 15;26(18):5602
White mice	Plague infection model	Oral	20 mg	Twice a day for 10 days	To assess the curative value of sulfathiazole in plague infection, results showed remarkable curative action	Bull World Health Organ. 1953;9(5):637-43
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Sulfathiazole/磺胺噻唑 参考文献

Sulfathiazole/磺胺噻唑 实验方案

计算器	摩尔计算器 总药量计算器 工作液计算器
存储液制备		1mg	5mg	10mg
	1 mM 5 mM 10 mM	3.92mL 0.78mL 0.39mL	19.58mL 3.92mL 1.96mL	39.17mL 7.83mL 3.92mL

Sulfathiazole/磺胺噻唑 技术信息