Sulfamethazine sodium is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg. Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. Moreover, a reduction in water intake caused a lower than anticipated dose of sulfamethazine. Under the conditions of the experiment the administration of sulfonamide in drinking water may be an effective means of mass medication of cattle[2].
Sulfamethazine Sodium Salt/磺胺二甲嘧啶钠盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rice plants
200 µm or 2mM
24 h
Sulfamethazine treatment significantly reduced rice susceptibility to root-knot nematodes, decreasing the number of galls and nematodes.
Mol Plant Pathol. 2021 Apr;22(4):440-455.
Sulfamethazine Sodium Salt/磺胺二甲嘧啶钠盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Hypertension model
Oral
1 mg/ml
Two weeks
Infection prophylaxis
Hypertension. 2016 Feb;67(2):461-8
Angus-cross beef cattle
Experimental confined feeding operation
Feed additive
350 mg
Once daily for 27.5 weeks
To investigate the effect of sulfamethazine in combination with chlortetracycline on the development of antimicrobial resistance in the enteric bacterial community of beef cattle. Results showed AS700 treatment increased the carriage of tetB, tetC, tetM, and tetW in the enteric bacterial community.
Microorganisms. 2019 Dec 21;8(1):23
Northern cricket frogs (Acris crepitans)
Bd-exposed frogs
Bath
14.5 mg/L
24 hours
To reduce the skin bacterial community, prior to exposing these animals to Bd under two different ecologically relevant temperatures.
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