Solasonine is a natural product isolated and purified from the herbs of Solanum nigrum L.
Solasonine/澳洲茄碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Pig cecal suspension
1 µM
0-24 hours
Investigate the degradation of Solasonine in the pig cecum model. Results showed that Solasonine was completely metabolized within 10 minutes, releasing its aglycone solasodine at a concentration of around 800 nM. Subsequently, the concentration of solasodine gradually decreased over time, reaching 196±252 nM after 24 hours.
ACS Omega. 2023 May 12;8(20):18266-18274
MDA-MB-231 cells
3 μg/mL
24 hours
SS inhibits the proliferation, migration, and invasion of MDA-MB-231 cells and activates ferroptosis by inhibiting the ERK2/MAPK signaling pathway.
Cancer Cell Int. 2025 Feb 17;25(1):49
MCF-7 cells
3 μg/mL
24 hours
SS inhibits the proliferation, migration, and invasion of MCF-7 cells and activates ferroptosis by inhibiting the ERK2/MAPK signaling pathway.
Cancer Cell Int. 2025 Feb 17;25(1):49
SGC-7901 human gastric cancer cells
18 µM
24 hours
Solasonine mainly induced cell cycle arrest at G2 phase in SGC-7901 cells, significantly down-regulated Bcl-2 and Caspase-3 protein expression, and reduced Bax and Bcl-xL protein expression.
J Cell Mol Med. 2022 Jun;26(12):3387-3395
SGC-7901 human gastric cancer cells
1, 2.5, 5, 10, 20, 30, 50 μg/ml
24 hours
Solasonine remarkably suppressed the in vitro proliferation of SGC-7901 cells in a dose-dependent manner, with a 24-hour IC50 value of 18 μM, comparable to cisplatin (17.5 μM).
To evaluate the effect of Solasonine on the growth of A549 cells, the results showed that Solasonine inhibited cell growth and induced cell death in a dose-dependent manner.
Front Oncol. 2022 May 18;12:874900
Calu-1 cells
10, 15, 20 µM
24 hours
To evaluate the effect of Solasonine on the growth of Calu-1 cells, the results showed that Solasonine inhibited cell growth and induced cell death in a dose-dependent manner.
To evaluate the cytotoxic effect of Solasonine on HepG2 cells, the results showed an IC50 of 91.8 ± 9.4 μM, indicating weaker antiproliferative effects against HepG2 cells.
Sci Rep. 2019 Feb 11;9(1):1746
Huh-7 cells
10.3 ± 1.5 µM (IC50)
72 hours
To evaluate the cytotoxic effect of Solasonine on Huh-7 cells, the results showed an IC50 of 10.3 ± 1.5 μM, indicating significant antiproliferative effects against Huh-7 cells.
Sci Rep. 2019 Feb 11;9(1):1746
Solasonine/澳洲茄碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Cutaneous leishmaniasis model
Topical administration
10 μM solasonine per mouse per day
Daily administration for 6 weeks
Evaluate the therapeutic effect of Solasonine on cutaneous leishmaniasis, showing significant reduction in lesion sizes and parasite counts.
SS activates ferroptosis by inhibiting the ERK2/MAPK signaling pathway, thereby inhibiting the growth and proliferation of breast carcinoma xenografts.
Cancer Cell Int. 2025 Feb 17;25(1):49
BALB/c nude mice
THP-1 cell xenograft model
Intraperitoneal injection
4, 8, or 16 mg/kg
Once daily for 14 days
Inhibited tumor growth through activation of the AMPK/FOXO3A axis
Toxins (Basel). 2018 Nov 23;10(12):487
BALB/c nude mice
THP-1 cell xenograft model
Intraperitoneal injection
4, 8, or 16 mg/kg
Once daily for 14 days
Inhibited tumor growth through activation of the AMPK/FOXO3A axis
Front Oncol. 2021 Jan 29;10:614067
Nude mice
Pancreatic cancer xenograft model
Oral administration
40 or 80 mg/kg
Twice a week for 5 weeks
Solasonine inhibited tumor formation and metastasis and reduced the expression of drug resistance-related proteins (MRP1 and P-gp).
Front Oncol. 2022 Apr 12;12:834729
Nude mice
HepG2-Luc xenograft tumor model
Intraperitoneal injection
5 mg/kg and 20 mg/kg
Once daily for 15 days
Inhibited HepG2-Luc xenograft tumor growth, increased miR-375-3p expression, and decreased CCAT1, SP1, and IRF5 levels
Front Oncol. 2019 Oct 18;9:1081
Galleria mellonella
Larvae
Diet
Three concentrations: SolA (1.49×10⁻³ mg/1 g diet), SolB (7.465×10⁻⁴ mg/1 g diet), SolC (3.825×10⁻⁴ mg/1 g diet)
Three days
To evaluate the effects of S. nigrum extract and solasonine on the physiology of G. mellonella larvae. Results showed that solasonine altered hemolymph metabolites and the ultrastructure of fat body and midgut cells.
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