There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Scoparone, a natural product isolated and purified from the herbs of Artemisia scoparia, with antifungal, antianginal, antioxidant, immunosuppression and vasorelaxation effects, protects against carbon tetrachloride-induced liver injury, is a very efficient inhibitor of ultraviolet radiation -induced lipid peroxidation and damage, and a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.
Scoparone/滨蒿内酯 细胞实验
Cell Line
Concentration
Treated Time
Description
References
bone marrow-derived macrophages (BMDMs)
bone marrow-derived macrophages (BMDMs)
significantly inhibited caspase-1 cleavage, GSDMD-mediated pyroptosis, mature IL-1β secretion and the formation of ASC specks
Acta Pharmacol Sin. 2023 Jun;44(6):1238-1251.
mouse macrophage J774A.1 cells
mouse macrophage J774A.1 cells
significantly inhibited caspase-1 cleavage, GSDMD-mediated pyroptosis, mature IL-1β secretion and the formation of ASC specks
Acta Pharmacol Sin. 2023 Jun;44(6):1238-1251.
Huh7 cells
Huh7 cells
Scoparone significantly potentiated the activation of the BSEP promoter by CDCA, and this potentiation was enhanced in cells transfected with CYP1A2.
Br J Pharmacol. 2011 Nov;164(5):1547-57.
Primary human hepatocytes
Primary human hepatocytes
Scoparone significantly increased CYP2B6 mRNA expression at 100 μM but had no significant effect on UGT1A1 or BSEP expression.
Br J Pharmacol. 2011 Nov;164(5):1547-57.
HepG2 cells
HepG2 cells
Inhibited STAT3 transcriptional activity, reduced cyclin D and M67 promoter activity
Exp Mol Med. 2015 Mar 6;47(3):e145.
vascular smooth muscle cells (VSMCs)
vascular smooth muscle cells (VSMCs)
Inhibited serum-stimulated VSMC proliferation, significantly reduced S phase cell accumulation, increased G0/G1 phase cell proportion, and decreased expression of cyclin D1, phosphorylated Rb, and survivin
Exp Mol Med. 2015 Mar 6;47(3):e145.
AML12 cells
AML12 cells
To observe the effect of scoparone on lipotoxic injured hepatocytes. Results showed that scoparone significantly improved PA-induced lipid deposition and apoptosis in hepatocytes.
Front Pharmacol. 2022 May 3;13:863756.
HepG2 cells
HepG2 cells
To observe the effect of scoparone on lipotoxic injured hepatocytes. Results showed that scoparone significantly improved PA-induced lipid deposition and apoptosis in hepatocytes.
Front Pharmacol. 2022 May 3;13:863756.
Scoparone/滨蒿内酯 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
Bacterial enteritis and septic shock models
Intraperitoneal injection and intragastric administration
50 mg/kg
Single dose followed by observation after 12 hours for septic shock model; continuous administration for 9 days for enteritis model
Scoparone significantly improved the survival rate of mice infected with bacteria, inhibited the secretion of IL-1β and TNF-α in serum, and reduced the infiltration of inflammatory cells in the lung, colon and liver
Acta Pharmacol Sin. 2023 Jun;44(6):1238-1251.
Mice
Mice
Intraperitoneal injection
10 mg/kg
Twice, 12 hours apart
Scoparone robustly activated the human BSEP promoter and significantly enhanced the expression of the endogenous mouse bsep gene.
Br J Pharmacol. 2011 Nov;164(5):1547-57.
C57BL/6J mice
HFD-induced NASH model
Oral
25, 50, and 100 mg/kg
Once daily for 8 weeks
To investigate the effect of scoparone on NASH mice. Results showed that scoparone significantly improved histopathological changes of liver tissues including mitochondrial number and morphology, lipid peroxide content, hepatosteatosis and inflammation, and decreased serum lipid and transaminase levels.
Front Pharmacol. 2022 May 3;13:863756.
New Zealand rabbits
Hyperlipidaemic diabetic rabbit model
Subcutaneous injection
5 mg/kg
Once daily for 6 weeks
Scoparone significantly reduced plasma lipid and lipoprotein cholesterol levels and protected against pathological alterations in vascular morphology and reactivity in hyperlipidaemic diabetic rabbits.
Br J Pharmacol. 1993 Dec;110(4):1508-14
Mice
Maximal electroshock-induced (MES) tonic-clonic seizure model
Intraperitoneal injection
199.8 mg/kg to 320.1 mg/kg
15, 30, 60 and 120 minutes
To evaluate the anticonvulsant effects of Scoparone in the mouse maximal electroshock model
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