Sarafloxacin Hydrochloride is a quinolone antibiotic drug. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model[3]. Based on a minimum inhibitory concentration (MIC) of 0.00625 to 0.045 μg/mL for susceptible strains, sarafloxacin p.o. administration at a dose 10 mg/kg could be efficacious against common pathogenic bacteria of fish[4].
Sarafloxacin HCl/沙拉沙星盐酸盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Yersinia ruckeri
0.02-0.06 μg/ml
6 days
To determine the antimicrobial activity of Sarafloxacin at different temperatures, showing higher MIC values at 4°C than at 15°C.
Clinically resistant Salmonella strains (Typhimurium B2, Derby A2, London E1)
4 μg/mL, 8 μg/mL, 2 μg/mL
8 h
To evaluate the effect of L-leucine on the bactericidal activity of Sarafloxacin, results showed that L-leucine significantly enhanced the bactericidal effect of Sarafloxacin on these clinically resistant strains.
Front Microbiol. 2023 May 12;14:1186841.
Salmonella Typhimurium (SAR-R)
16 μg/mL
8 h
To evaluate the effect of L-leucine on the bactericidal activity of Sarafloxacin, results showed that L-leucine significantly enhanced the bactericidal effect of Sarafloxacin on SAR-R.
Front Microbiol. 2023 May 12;14:1186841.
Sarafloxacin HCl/沙拉沙星盐酸盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Atlantic salmon
Seawater aquaculture
Intravenous and oral
10 mg/kg
Single dose
To compare the pharmacokinetic properties of four quinolones in Atlantic salmon, showing Sarafloxacin had a bioavailability of 2.2% and an elimination half-life of 24 hours.
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