Sal003
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货号：A690119
Sal003是 eIF2α 脱磷酸酶抑制剂 Salubrinal 的细胞透过性改良版，具有更好的水溶性。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type HazMat fee for 500 gram (Estimated) Excepted Quantity USD 0.00 Limited Quantity USD 15-60 Inaccessible (Haz class 6.1), Domestic USD 80+ Inaccessible (Haz class 6.1), International USD 150+ Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+ Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Sal003 化学结构
Sal003 3D分子结构
规格
价格
会员价
库存
数量
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Sal003 纯度/质量文件 产品仅供科研
货号：A690119
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Science , 2025, 387(6729): eadp5637. Ambeed. • Nat. Mater. , 2025, 24, 1116-1125. Ambeed. • Nat. Electron. , 2025, 8, 66-74. Ambeed. • Nano-Micro Lett. , 2025, 17, 311. Ambeed. • Adv. Mater. , 2025, 2416621. Ambeed. 更多 >
Sal003 质控信息
Sal003 生物活性
描述
Sal003 is a salubrinal derivate which can inhibit eIF2α dephosphorylation[5] [6] [7]
Sal003 动物研究
Dose
Mice: 1.5 mg/kg[4]
Administration
Intratumor injection
Sal003 参考文献
[1] Robert F, Kapp LD, et al. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell. 2006 Nov;17(11):4632-44. Epub 2006 Aug 23.
[2] Baltzis D, Pluquet O, et al. The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J Biol Chem. 2007 Oct 26;282(43):31675-87. Epub 2007 Sep 4.
[3] Costa-Mattioli M, Gobert D, et al. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206.
[4] Darini C, Ghaddar N, et al. An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy. Nat Commun. 2019 May 13;10(1):2139.
[5] Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, Pelletier J. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell. 2006 Nov;17(11):4632-44. doi: 10.1091/mbc.e06-06-0478. Epub 2006 Aug 23. PMID: 16928960; PMCID: PMC1635388.
[6] Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE. The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J Biol Chem. 2007 Oct 26;282(43):31675-87. doi: 10.1074/jbc.M704491200. Epub 2007 Sep 4. PMID: 17785458.
[7] Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille JC, Nader K, Sonenberg N. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206. doi: 10.1016/j.cell.2007.01.050. PMID: 17418795; PMCID: PMC4149214.
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Sal003 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.16mL
0.43mL
0.22mL
10.79mL
2.16mL
1.08mL
21.59mL
4.32mL
2.16mL
Sal003 技术信息
搜索
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