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SAG HCl {[allProObj[0].p_purity_real_show]}

货号：A125368 同义名： SAG hydrochloride

SAG HCl是一种高效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)，可激活 Hedgehog 信号通路，并抵消 Cyclopamine 对 Smo 的抑制。

SAG HCl 化学结构 CAS号：2095432-58-7
SAG HCl 化学结构
CAS号：2095432-58-7
SAG HCl 3D分子结构
CAS号：2095432-58-7
SAG HCl 化学结构 CAS号：2095432-58-7
SAG HCl 3D分子结构 CAS号：2095432-58-7
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SAG HCl 纯度/质量文件 产品仅供科研

货号：A125368 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
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SAG HCl 生物活性

描述 SAG hydrochloride is a highly effective agonist of the Smoothened (Smo) receptor (EC50=3 nM; KD=59 nM). It activates the Hedgehog signaling pathway and antagonizes the inhibitory effects of Cyclopamine on Smo[1][2][3].
体内研究

SAG (1.0 mM) primarily promotes osteogenesis, particularly at the borders of defects, and leads to a significant increase in BV/TV at the eight-week time point in CD-1 mice[4].

SAG HCl 细胞实验

Cell Line
Concentration Treated Time Description References
Primary hepatic cells 0.25–2.00 mM 1 h SAG pre-treatment significantly protected against cytotoxicity induced by CCl4 and significantly reduced AST and ALT levels. Int J Mol Sci. 2022 Apr 17;23(8):4429.
human adipose-derived mesenchymal stem cells (ASCs) 200 nM 24 h Activate the Hedgehog signaling pathway and detect the accumulation of Smo in cilia. Results showed that SAG treatment increased the accumulation of Smo in cilia, indicating the activation of the Hedgehog pathway. Stem Cell Reports. 2018 Feb 13;10(2):583-599.
NIH 3T3 cells 1 μM 48 h To detect defects in downstream Shh signaling in Chmp1a null and control MEFs, measured by Gli1 activation, showing no significant defect. Cell Rep. 2018 Jul 24;24(4):973-986.e8.
SVG-A cells 1 μM 48 h Activation of SHH signaling, inducing GLI1 and PTCH expression, showing no significant difference between CHMP1A null and WT cells. Cell Rep. 2018 Jul 24;24(4):973-986.e8.

SAG HCl 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Ick-mutant mice Intraperitoneal injection 20 mg/kg Single injection, embryos harvested between E12.5 and E18.5 By activating the SHH signaling pathway, SAG treatment successfully rescued congenital defects in Ick-mutant mice, including cleft palate. EBioMedicine. 2019 Nov;49:305-317
BALB/c mice Listeria infection model Subcutaneous injection 50 µg,100 μL Booster immunization 3 weeks after the first immunization To evaluate the immunological response and protective efficacy of archaeosome-encapsulated SAgs in BALB/c mice, the results showed that archaeosome-encapsulated SAgs significantly upregulated Th1 cytokine production and reduced bacterial burden in infected mice. Int J Nanomedicine. 2012;7:2433-47
Mice Cfp1d/d mouse model Intrauterine injection 1000 nM,10 μL Single injection, sacrificed at 3 or 21 hours SAG successfully rescued aberrant uterine cell proliferation and gene expression in Cfp1d/d female mice. Nat Commun. 2023 Jun 3;14(1):3220
Mice MCAo model Gavage 10mg/kg Once daily for 6 days To evaluate the role of SAG in post-stroke functional recovery, results showed that SAG treatment significantly improved motor and cognitive functions and increased the survival of newly generated cells. Stroke. 2017 Jun;48(6):1636-1645
Mice CCl4-induced liver injury model Oral 30 mg/kg Twice a week for 8 weeks SAG significantly restored SOD activity, GSH levels, and GPx activity, while it strongly reduced GSSG levels, lipid peroxidation, and H2O2 and ROS levels. SAG also reduced inflammation and fibrosis, improved liver function and mitophagy. Int J Mol Sci. 2022 Apr 17;23(8):4429.

SAG HCl 动物研究

Dose Mice: 15 mg/kg - 20 mg/kg[3] (i.p.)
Administration i.p.

SAG HCl 参考文献

[1]Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

[2]Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.

[3]Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811.

[4]Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13.

SAG HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.50mL

1.90mL

0.95mL

18.99mL

3.80mL

1.90mL

SAG HCl 技术信息

CAS号2095432-58-7
分子式C28H29Cl2N3OS
分子量 526.52
SMILES Code O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4.[H]Cl
MDL No. N/A
别名 SAG hydrochloride
运输蓝冰
InChI Key CRWTYWYPPITOOZ-UHFFFAOYSA-N
Pubchem ID 121540649
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 20 mg/mL(37.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(47.48 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: SAG | 2095432-58-7 | Smo | Smoothened | Smoothened Agonist | Stem Cell/Wnt | Smo | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | SAG HCl 纯度/质量文件 | SAG HCl 生物活性 | SAG HCl 动物研究 | SAG HCl 参考文献 | SAG HCl 实验方案 | SAG HCl 技术信息

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