Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
Rubusoside/甜茶苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
GLUT1
20 mM
1 minute
Rub inhibits GLUT1-mediated glucose transport with an IC50 of 4.6 ± 0.3 mM.
Sci Rep. 2015 Aug 26;5:12804
GLUT5
20 mM
1 minute
Rub inhibits GLUT5-mediated fructose transport with an IC50 of 6.7 ± 0.2 mM.
Sci Rep. 2015 Aug 26;5:12804
MCF-7 cells
23 µM CUR and 110 µM RES
24 hours
To evaluate the anti-cancer effect of RUB/CUR + RES micelles on MCF-7 cells, results showed that RUB/CUR + RES micelles had more significant toxicity on MCF-7 cells compared to RUB/CUR micelles + RUB/RES micelles.
Nanoscale Res Lett. 2017 Dec;12(1):274
Streptococcus mutans ATCC25175
1%
5 days
To evaluate the effect of Rubusoside on Streptococcus mutans biofilm formation and virulence gene expression. Results showed that Rubusoside significantly reduced biofilm accumulation, bacterial viability, and polysaccharide production, and inhibited virulence gene expression.
Appl Environ Microbiol. 2020 Aug 3;86(16):e01012-20
Rubusoside/甜茶苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
OVCAR-3 or A2780 xenograft tumor model
Intraperitoneal injection
1 mg/kg
Once every 3 days for 24 days
To evaluate the effect of Cer-RUB nanomicelles on tumor growth, results showed that Cer-RUB nanomicelles significantly inhibited the growth of OVCAR-3 tumors
Mol Cancer Ther. 2020 Feb;19(2):564-574
Sprague Dawley rats
Pre-cannulated rat model
Oral gavage and intravenous injection
Oral 20 mg/kg, intravenous 2 mg/kg
Single dose, observed for 24 hours
Compare pharmacokinetic parameters of Nano-PTX and Taxol? formulations in rat model, results showed oral bioavailability of Nano-PTX formulation was 1.7%, 88% higher than Taxol? formulation (1.3%)
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