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/ Ribostamycin Sulfate/硫酸核糖霉素

Ribostamycin Sulfate/硫酸核糖霉素 {[allProObj[0].p_purity_real_show]}

货号：A391931 同义名： Vistamycin sulfate

Ribostamycin Sulfate是一种广谱抗菌药，从Streptomyces ribosifidicus中分离得到，通过结合细菌的30S和50S核糖体亚基，抑制肽酰-tRNA从A位点到P位点的转运，从而导致mRNA的错误解码。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ribostamycin Sulfate/硫酸核糖霉素 化学结构 CAS号：53797-35-6
Ribostamycin Sulfate/硫酸核糖霉素 化学结构
CAS号：53797-35-6
Ribostamycin Sulfate/硫酸核糖霉素 3D分子结构
CAS号：53797-35-6
Ribostamycin Sulfate/硫酸核糖霉素 化学结构 CAS号：53797-35-6
Ribostamycin Sulfate/硫酸核糖霉素 3D分子结构 CAS号：53797-35-6
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Ribostamycin Sulfate/硫酸核糖霉素 纯度/质量文件 产品仅供科研

货号：A391931 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ribostamycin Sulfate/硫酸核糖霉素 生物活性

描述 Ribostamycin Sulfate is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. The binding affinity of ribostamycin to purified bovine PDI (protein disulfide isomerase) was 319 μM (K(D) value)[3]. Moreover, MIC(90) of ribostamycin is 32 mg/L)[4]. The linear relationship of ribostamycin sulfate and kanamycin between concentration and peak height was obtained in the concentration range of 0.18-1.08 mM and 0.31-1.86 mM and the determination limit was 7. 2 nM and 46 nM respectively[5]. The Cmax in children and infants after intramuscular ribostamycin 10 mg/kg approached that in adults after an intramuscular dose of ribostamycin 500 mg. It is suggested that ribostamycin was administered in intramuscular doses of 10 to 15 mg/kg twice daily in infants and 3 times daily in children, respectively[6].

Ribostamycin Sulfate/硫酸核糖霉素 细胞实验

Cell Line
Concentration Treated Time Description References
bacterial ribosomes 0.13 μM Investigated the impact of Ribostamycin on ribosome subunit rotation dynamics, showing weak effects on rotation dynamics. Nat Commun. 2015 Jul 30;6:7896.
MDCK cells >100 mM 68 h Evaluate the nephrotoxicity of ribostamycin in MDCK cells, showing no toxicity Front Microbiol. 2020 Jul 29;11:1718.
HEK293 cells >100 mM 68 h Evaluate the nephrotoxicity of ribostamycin in HEK293 cells, showing no toxicity Front Microbiol. 2020 Jul 29;11:1718.
Streptococcus pneumoniae (ATCC 49619) 7.2 μM 14 h Evaluate the antibacterial activity of ribostamycin against S. pneumoniae, showing high activity Front Microbiol. 2020 Jul 29;11:1718.
Haemophilus influenzae (ATCC 49247) 0.5 μM 14 h Evaluate the antibacterial activity of ribostamycin against H. influenzae, showing high activity Front Microbiol. 2020 Jul 29;11:1718.
Escherichia coli (ATCC 35218) 57.9 μM 14 h Evaluate the antibacterial activity of ribostamycin against β-lactam-resistant E. coli, showing lower activity Front Microbiol. 2020 Jul 29;11:1718.
Escherichia coli (ATCC 25922) 29.0 μM 14 h Evaluate the antibacterial activity of ribostamycin against E. coli, showing moderate activity Front Microbiol. 2020 Jul 29;11:1718.

Ribostamycin Sulfate/硫酸核糖霉素 参考文献

[1]Horibe T, Nagai H, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72.

[2]Hunfeld KP, Weigand J, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.

[3] Horibe T, Nagai H, Sakakibara K, Hagiwara Y, Kikuchi M. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001;289(5):967‐972.

[4]Hunfeld KP, Weigand J, Wichelhaus TA, Kekoukh E, Kraiczy P, Brade V. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001;17(3):203‐208.

[5]Liang YA, Zhang TM. Yao Xue Xue Bao. 1992;27(2):157‐160.

[6]Zhou SL, Shen G, Zhong HF. Pharmacokinetics of ribostamycin in paediatric patients. Clin Pharmacokinet. 1992;22(2):144‐151.

Ribostamycin Sulfate/硫酸核糖霉素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.05mL

1.81mL

0.90mL

18.10mL

3.62mL

1.81mL

Ribostamycin Sulfate/硫酸核糖霉素 技术信息

CAS号53797-35-6
分子式C17H36N4O14S
分子量 552.55
SMILES Code O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
MDL No. MFCD23380549
别名 Vistamycin sulfate
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

H2O: 120 mg/mL(217.17 mM)，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Ribostamycin | 53797-35-6 | Vistamycin | Bacterial Inhibitor | Anti-infection | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage | Bacterial | Antibiotic | PDI | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ribostamycin Sulfate/硫酸核糖霉素 纯度/质量文件 | Ribostamycin Sulfate/硫酸核糖霉素 生物活性 | Ribostamycin Sulfate/硫酸核糖霉素 参考文献 | Ribostamycin Sulfate/硫酸核糖霉素 实验方案 | Ribostamycin Sulfate/硫酸核糖霉素 技术信息

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