Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293)
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货号：A2924007同义名：
重组大鼠SCF蛋白(C-6His, HEK293)
/ Recombinant Rat SCF (C-6His, HEK293); FPH2
Recombinant Rat SCF (C-6His, HEK293)是来自大鼠的重组蛋白，在HEK293人源细胞中表达，带有C端6×His标签。该蛋白即SCF/C-kit配体，是KIT基因编码的酪氨酸激酶受体的配体，在调控细胞存活增殖、造血、干细胞维持、配子发生、肥大细胞发育迁移及功能、黑色素生成中起重要作用，还能激活多条信号通路，临床联合G-CSF可提升CD34阳性细胞数量。
Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293) 质控信息
Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293) 生物活性
描述
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Rat SCF (C-6His, HEK293)/大鼠SCF蛋白(C-6His, HEK293) 技术信息
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